Bicyclic 5-6 Systems: Three Heteroatoms 2:1
Résumé
This is a review of the chemistry, pharmacological and biomedical applications of bicyclic 5-6 systems possessing a five-membered ring with two heteroatoms fused onto a six-membered ring with one heteroatom. During the last decade the synthesis and transformations of these bicyclic 5-6 systems, especially that of imidazo-, pyrazolo-, oxazolo-, thiazolo- and isothiazolopyridines have received considerable attention due to their biological significance. This review covers theoretical and structural properties and recent methodologies, such as direct C-H-bond activation, multicomponent reactions, chemoselective transformations, as well as other new innovative approaches to provide molecules for the drug-like chemical space. The review is focused on medicinal chemistry application of these heterocyclic systems.