Chapitre D'ouvrage Année : 2022

Bicyclic 5-6 Systems: Three Heteroatoms 2:1

Résumé

This is a review of the chemistry, pharmacological and biomedical applications of bicyclic 5-6 systems possessing a five-membered ring with two heteroatoms fused onto a six-membered ring with one heteroatom. During the last decade the synthesis and transformations of these bicyclic 5-6 systems, especially that of imidazo-, pyrazolo-, oxazolo-, thiazolo- and isothiazolopyridines have received considerable attention due to their biological significance. This review covers theoretical and structural properties and recent methodologies, such as direct C-H-bond activation, multicomponent reactions, chemoselective transformations, as well as other new innovative approaches to provide molecules for the drug-like chemical space. The review is focused on medicinal chemistry application of these heterocyclic systems.
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Dates et versions

hal-03553877 , version 1 (03-02-2022)

Identifiants

Citer

Janos Sapi, Stéphane Gérard. Bicyclic 5-6 Systems: Three Heteroatoms 2:1. Comprehensive Heterocyclic Chemistry IV, Elsevier, pp.212-382, 2022, ⟨10.1016/B978-0-12-818655-8.00021-4⟩. ⟨hal-03553877⟩
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