Adhesion-regulated junction slippage controls cell intercalation dynamics in an Apposed-Cortex Adhesion Model - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue PLoS Computational Biology Année : 2022

Adhesion-regulated junction slippage controls cell intercalation dynamics in an Apposed-Cortex Adhesion Model

Alexander Nestor-Bergmann
Guy Blanchard
Nathan Hervieux
Alexander Fletcher
Bénédicte Sanson

Résumé

Cell intercalation is a key cell behaviour of morphogenesis and wound healing, where local cell neighbour exchanges can cause dramatic tissue deformations such as body axis extension. Substantial experimental work has identified the key molecular players facilitating intercalation, but there remains a lack of consensus and understanding of their physical roles. Existing biophysical models that represent cell-cell contacts with single edges cannot study cell neighbour exchange as a continuous process, where neighbouring cell cortices must uncouple. Here, we develop an Apposed-Cortex Adhesion Model (ACAM) to understand active cell intercalation behaviours in the context of a 2D epithelial tissue. The junctional actomyosin cortex of every cell is modelled as a continuous viscoelastic rope-loop, explicitly representing cortices facing each other at bicellular junctions and the adhesion molecules that couple them. The model parameters relate directly to the properties of the key subcellular players that drive dynamics, providing a multi-scale understanding of cell behaviours. We show that active cell neighbour exchanges can be driven by purely junctional mechanisms. Active contractility and cortical turnover in a single bicellular junction are sufficient to shrink and remove a junction. Next, a new, orthogonal junction extends passively. The ACAM reveals how the turnover of adhesion molecules regulates tension transmission and junction deformation rates by controlling slippage between apposed cell cortices. The model additionally predicts that rosettes, which form when a vertex becomes common to many cells, are more likely to occur in actively intercalating tissues with strong friction from adhesion molecules.
Fichier principal
Vignette du fichier
journal.pcbi.1009812.pdf (3.03 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-03553820 , version 1 (04-10-2022)

Identifiants

Citer

Alexander Nestor-Bergmann, Guy Blanchard, Nathan Hervieux, Alexander Fletcher, Jocelyn Etienne, et al.. Adhesion-regulated junction slippage controls cell intercalation dynamics in an Apposed-Cortex Adhesion Model. PLoS Computational Biology, 2022, 18 (1), pp.e1009812. ⟨10.1371/journal.pcbi.1009812⟩. ⟨hal-03553820⟩

Collections

UGA CNRS LIPHY ANR
28 Consultations
18 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More