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Article Dans Une Revue Nature Medicine Année : 2014

Pathogenic Neisseria meningitidis utilizes CD147 for vascular colonization

Sandra C Bernard
  • Fonction : Auteur
Nandi Simpson
  • Fonction : Auteur
Nawal Maïssa
  • Fonction : Auteur
Fabrice Chretien
  • Fonction : Auteur
Saïd Taouji
  • Fonction : Auteur
Eric Chevet
Sébastien Janel
  • Fonction : Auteur
Frank Lafont
Audrey Segura
  • Fonction : Auteur
Florence Niedergang
Stefano Marullo
Xavier Nassif
Sandrine Bourdoulous

Résumé

Neisseria meningitidis is a cause of meningitis epidemics worldwide and of rapidly progressing fatal septic shock. A crucial step in the pathogenesis of invasive meningococcal infections is the adhesion of bloodborne meningococci to both peripheral and brain endothelia, leading to major vascular dysfunction. Initial adhesion of pathogenic strains to endothelial cells relies on meningococcal type IV pili, but the endothelial receptor for bacterial adhesion remains unknown. Here, we report that the immunoglobulin superfamily member CD147 (also called extracellular matrix metalloproteinase inducer (EMMPRIN) or Basigin) is a critical host receptor for the meningococcal pilus components PilE and PilV. Interfering with this interaction potently inhibited the primary attachment of meningococci to human endothelial cells in vitro and prevented colonization of vessels in human brain tissue explants ex vivo and in humanized mice in vivo. These findings establish the molecular events by which meningococci target human endothelia, and they open new perspectives for treatment and prevention of meningococcus-induced vascular dysfunctions.

Dates et versions

hal-03552952 , version 1 (12-12-2023)

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Citer

Sandra C Bernard, Nandi Simpson, Olivier Join-Lambert, Christian Federici, Marie-Pierre Laran-Chich, et al.. Pathogenic Neisseria meningitidis utilizes CD147 for vascular colonization. Nature Medicine, 2014, 20, pp.725 - 731. ⟨10.1038/nm.3563⟩. ⟨hal-03552952⟩
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