Physico-chemical characterization of ferrocifen loaded lipid nanocapsules: different drug delivery systems depending on succinimido-ferrociphenol structure - Archive ouverte HAL Accéder directement au contenu
Poster De Conférence Année : 2021

Physico-chemical characterization of ferrocifen loaded lipid nanocapsules: different drug delivery systems depending on succinimido-ferrociphenol structure

Pierre Idlas
Elise Lepeltier
Pascal Pigeon
Gérard Jaouen

Résumé

The resistance to the current chemotherapeutic drugs has obliged the scientific community to seek innovative strategies (molecules, nanoparticles or gel). In the late 1990s, Jaouen’s team synthesized a new class of bio-organometallic molecules called ferrocifens [1]. However, their high lipophilic nature requires a formulation stage before being administered in vivo. Lipid nanocapsules (LNCs), developed in 2001 [2], have shown their ability to successfully encapsulated ferrocifens. In last decades, ferrocifen loaded LNCs have demonstrated anticancer properties on multidrug-resistant cancers (glioblastoma, metastatic melanoma, breast cancer) on mice models [3]. The most recent family of ferrocifens (the succinimido-ferrociphenols) seems to be the most efficient on several resistant cancer cell lines, with IC50 in the nanomolar range [4]. As LNCs are composed of anoily core (caprylic/capric triglycerides), playing with the lipophilicity of the succinimido-ferrociphenols can be interesting to improve the drug loading in LNCs. In the present work, 50 nm LNCs loaded with six different succinimido-ferrociphenols were formulated. For each ferrocifen, the maximal drug loading was determined. Interestingly, the encapsulation of two ferroficens led to the formation of gels: it is unprecedent. In order to understand this phenomenon, tensiometry measurements were performed to determine a potential influence of the ferrocifen position in the LNCs.
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Dates et versions

hal-03552215 , version 1 (02-02-2022)

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  • HAL Id : hal-03552215 , version 1

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Pierre Idlas, Elise Lepeltier, Pascal Pigeon, Gérard Jaouen, Catherine Passirani. Physico-chemical characterization of ferrocifen loaded lipid nanocapsules: different drug delivery systems depending on succinimido-ferrociphenol structure. SFNano2021, Annual Meeting, Dec 2021, ANGERS, France. ⟨hal-03552215⟩
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