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Journal Articles Proceedings of the National Academy of Sciences of the United States of America Year : 2021

Physical bioenergetics: Energy fluxes, budgets, and constraints in cells

Xingbo Yang
  • Function : Author
  • PersonId : 1140590
Matthias Heinemann
Jonathon Howard
Greg Huber
Srividya Iyer-Biswas
Guillaume Le Treut
Michael Lynch
Kristi L Montooth
Daniel J Needleman
Simone Pigolotti
Jonathan Rodenfels
Sadasivan Shankar
  • Function : Author
Iman Tavassoly
  • Function : Author
Shashi Thutupalli
Denis V Titov
Jin Wang
  • Function : Author
Peter J Foster
  • Function : Author
  • PersonId : 1140591

Abstract

Cells are the basic units of all living matter which harness the flow of energy to drive the processes of life. While the biochemical networks involved in energy transduction are well-characterized, the energetic costs and constraints for specific cellular processes remain largely unknown. In particular, what are the energy budgets of cells? What are the constraints and limits energy flows impose on cellular processes? Do cells operate near these limits, and if so how do energetic constraints impact cellular functions? Physics has provided many tools to study nonequilibrium systems and to define physical limits, but applying these tools to cell biology remains a challenge. Physical bioenergetics, which resides at the interface of nonequilibrium physics, energy metabolism, and cell biology, seeks to understand how much energy cells are using, how they partition this energy between different cellular processes, and the associated energetic constraints. Here we review recent advances and discuss open questions and challenges in physical bioenergetics.

Dates and versions

hal-03541341 , version 1 (03-03-2022)

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Xingbo Yang, Matthias Heinemann, Jonathon Howard, Greg Huber, Srividya Iyer-Biswas, et al.. Physical bioenergetics: Energy fluxes, budgets, and constraints in cells. Proceedings of the National Academy of Sciences of the United States of America, 2021, 118 (26), pp.e2026786118. ⟨10.1073/pnas.2026786118⟩. ⟨hal-03541341⟩
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