Isoprostanoids, Isofuranoids and Isoketals ‐ From Synthesis to Lipidomics
Résumé
A huge diversity of oxygenated metabolites originated
from polyunsaturated fatty acids (PUFAs) had been discovered
discovered. Radical cascades are involved in the biosynthesis of
these metabolites, and the radical initiation can be performed either
inside the active site of an enzyme in the extracellular medium, or in
membrane on phospholipids. The development of convergent and
flexible chemical strategies to prepare these compounds by organic
chemists, along with the development of sophisticated mass
spectrometry methods has boosted the knowledge regarding PUFA
metabolites. Also, isoprostanoids have emerged as indicators of
oxidative stress in humans and their environment. This review
provides a brief overview on the chemical strategies and analytical
methods achieved over the past thirty years.