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Article Dans Une Revue European Journal of Organic Chemistry Année : 2016

Recent Advances in the Synthesis of Flavaglines, a Family of Potent Bioactive Natural Compounds Originating from Traditional Chinese Medicine

Résumé

Flavaglines constitute a distinctive family of plant metabolites isolated from medicinal plants of the genus Aglaia. These compounds exhibit a broad spectrum of distinctive pharmacological properties, including anti-inflammatory, neuroprotective, cardioprotective, and anticancer activities. These natural cyclopenta[b]benzofurans are characterized by densely functionalized tricyclic frameworks, as exemplified by the structures of rocaglamide or silvestrol, which makes them extremely attractive targets for total synthesis, in addition to their therapeutic potential. In this review we describe the various synthetic approaches to the total synthesis of flavaglines, culminating in a new generation of diastereo- and enantioselective total syntheses.

Domaines

Chimie organique

Dates et versions

hal-03533707 , version 1 (18-01-2022)

Identifiants

Citer

Qian Zhao, Hussein Abou Hamdan, Laurent Désaubry. Recent Advances in the Synthesis of Flavaglines, a Family of Potent Bioactive Natural Compounds Originating from Traditional Chinese Medicine. European Journal of Organic Chemistry, 2016, 2016 (36), pp.5908-5916. ⟨10.1002/ejoc.201600437⟩. ⟨hal-03533707⟩
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