This article investigates the potential detrimental effects of cyclic load during the installation of externally bonded (EB) carbon fiber-reinforced polymer (CFRP) on a damaged reinforced concrete (RC) structure. Four RC specimens were tested in three point bending to study the consequences of crack cyclic opening-closure during epoxy-curing period. A first RC specimen (without bonded CFRP) was loaded monotonically up to failure to serve as undamaged control sample. The three other specimens were pre-cracked before being subjected to a fatigue loading procedure to simulate service condition of a damaged RC structure. Two of the three pre-cracked specimens were strengthened by EB CFRP. One specimen was repaired before the fatigue test while the other one was repaired during the fatigue test. Finally, remaining capacities of all three pre-cracked specimens were measured through monotonic bending tests until failure. It was found that, although bonding of CFRP reinforcement during cyclic load can induce some interesting features with regard to serviceability, cyclic crack opening and closing alters the cure process of epoxy located below the initial crack and decreases the effectiveness of the strengthening at ultimate state. Extended experimental studies are then needed to assess reliable safety factor for the design of repairing operations in which the bridge has to be maintained in service during CFRP installation.