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Article Dans Une Revue Alzheimer's & Dementia : the Journal of the Alzheimer's Association Année : 2021

Personalized nutrition for dementia prevention

Hussein N. Yassine
  • Fonction : Auteur
Debora Melo van Lent
  • Fonction : Auteur
Ondine van de Rest
  • Fonction : Auteur
Gene L. Bowman
  • Fonction : Auteur
Nikolaos Scarmeas

Résumé

The role of nutrition has been investigated for decades under the assumption of one-size-fits-all. Yet there is heterogeneity in metabolic and neurobiological responses to diet. Thus a more personalized approach may better fit biological reality and have increased efficacy to prevent dementia. Personalized nutrition builds on the food exposome, defined as the history of diet-related exposures over the lifetime, and on its interactions with the genome and other biological characteristics (eg, metabolism, the microbiome) to shape health. We review current advances of personalized nutrition in dementia research. We discuss key questions, success milestones, and future roadmap from observational epidemiology to clinical studies through basic science. A personalized nutrition approach based on the best prescription for the most appropriate target population in the most relevant time-window has the potential to strengthen dementia-prevention efforts.
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Dates et versions

hal-03528345 , version 1 (17-01-2022)

Identifiants

Citer

Cecilia Samieri, Hussein N. Yassine, Debora Melo van Lent, Sophie Lefevre Arbogast, Ondine van de Rest, et al.. Personalized nutrition for dementia prevention. Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2021, ⟨10.1002/alz.12486⟩. ⟨hal-03528345⟩

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