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Article Dans Une Revue Synthetic Communications Année : 2013

Synthesis of primary amines by one-pot reductive amination of aldehydes.

Résumé

We report here a novel, one-pot, two-step reductive amination of aldehydes for the atom-economical synthesis of primary amines. The amination step has been carried out with hydroxylammonium chloride and does not require the use of a base. In the subsequent reduction step, a metal zinc/hydrochloride acid system has been used. This method is applicable to both aliphatic and aromatic aldehydes. The operational simplicity, the short reaction times, and the mild reaction conditions add to the value of this method as a practical alternative to the reductive amination of aldehydes. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications1 to view the free supplemental file.
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Dates et versions

hal-03526056 , version 1 (14-01-2022)

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Mohamed Ali Ayedi, Yves Le Bigot, Houcine Ammar, Souhir Abid, Rachid El Gharbi, et al.. Synthesis of primary amines by one-pot reductive amination of aldehydes.. Synthetic Communications, 2013, 43 (6), pp.2127-2133. ⟨10.1080/00397911.2012.714830⟩. ⟨hal-03526056⟩
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