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Article Dans Une Revue Nature Ecology & Evolution Année : 2021

Spatial structure governs the mode of tumour evolution

Robert Noble
Dominik Burri
Cécile Le Sueur
  • Fonction : Auteur
Jeanne Lemant
  • Fonction : Auteur
Jakob Nikolas Kather
Niko Beerenwinkel

Résumé

Abstract Characterizing the mode—the way, manner or pattern—of evolution in tumours is important for clinical forecasting and optimizing cancer treatment. Sequencing studies have inferred various modes, including branching, punctuated and neutral evolution, but it is unclear why a particular pattern predominates in any given tumour. Here we propose that tumour architecture is key to explaining the variety of observed genetic patterns. We examine this hypothesis using spatially explicit population genetics models and demonstrate that, within biologically relevant parameter ranges, different spatial structures can generate four tumour evolutionary modes: rapid clonal expansion, progressive diversification, branching evolution and effectively almost neutral evolution. Quantitative indices for describing and classifying these evolutionary modes are presented. Using these indices, we show that our model predictions are consistent with empirical observations for cancer types with corresponding spatial structures. The manner of cell dispersal and the range of cell–cell interactions are found to be essential factors in accurately characterizing, forecasting and controlling tumour evolution.

Domaines

Cancer

Dates et versions

hal-03522550 , version 1 (12-01-2022)

Identifiants

Citer

Yannick Viossat, Robert Noble, Dominik Burri, Cécile Le Sueur, Jeanne Lemant, et al.. Spatial structure governs the mode of tumour evolution. Nature Ecology & Evolution, 2021, ⟨10.1038/s41559-021-01615-9⟩. ⟨hal-03522550⟩
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