This paper presents an overview of the main actions and projects of the theme B ‘Biomedical Signal and Image Processing’ of the GdR Stic-Santé. Several scientific meetings have been organized during the 2011–2012 period. They are always devoted to advanced signal and image processing that could bring innovative solutions to relevant medical applications. The theme has strong relationships with other GdRs and also organizes meetings in close coordination with these GdRs. It also supports two working groups with well-identified research projects. Prospects includes reinforcing communication and cooperation with the other GdRs, involving labs from other countries, and attracting private companies that could also share their needs in terms of developments for which the theme participants could offer solutions. The whole motivation is to enhance the fit between academic research, needs from the medical community and impact for medical research and applications.