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Article Dans Une Revue Journal of Current Viruses and Treatment Methodologies Année : 2020

Quantitative Computational Prediction of the Consensus B-cell Epitopes of 2019-nCoV

Raúl Isea

Résumé

The goal of this paper is to obtain the numerical consensus of B cell epitopes from the three-dimensional structure of the prefusion spike glycoprotein of the new betacoronavirus that could lead to the development of a vaccine to 2019-nCoV. In order to do that, we first calculated the B-cell epitopes that are predicted using fourteen different mathematical algorithms. Later, we obtained the consensus of B-cell epitopes according to the Similarity Index, and finally selecting the best candidates according to the results of a function called which is evaluated for the glycoprotein. The best candidates that we obtained in order to design a vaccine are SSANNCT, PLQSYGFQPT, TESNKKFLP, NNSYEC, AENS, LPDPSK and YDPLQPE.
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Dates et versions

hal-03519489 , version 1 (10-01-2022)

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Raúl Isea. Quantitative Computational Prediction of the Consensus B-cell Epitopes of 2019-nCoV. Journal of Current Viruses and Treatment Methodologies, 2020, 1 (1), pp.42 - 47. ⟨10.14302/issn.2691-8862.jvat-20-3278⟩. ⟨hal-03519489⟩
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