Recent synthetic methods towards the –OCHF2 moiety
Résumé
The fluorine atom and fluorinated substituents are currently key motifs in pharmaceutical and agrochemical active ingredients, since they often beneficially modulate the physico-chemical and biological properties of the latter when installed in place of a hydrogen substituent. Among such fluorinated moieties, –OCHF2 is emerging as an interesting group, which is notably capable of forming a hydrogen bond. These appealing properties have led to a growing need for introduction methods of this group. In this review we summarize all current methods allowing access to the –OCHF2 moiety. We will hence discuss procedures applicable to either aromatic or aliphatic substrates, and based on different disconnections, including difluoromethylation of alcohols, or radical addition onto arenes
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Manuscript Tetrahedron OCHF2_accepted version (1).pdf (1.73 Mo)
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