Agency Deficits in a Human Genetic Model of Schizophrenia: Insights From 22q11DS Patients - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Schizophrenia Bulletin Année : 2021

Agency Deficits in a Human Genetic Model of Schizophrenia: Insights From 22q11DS Patients

Roy Salomon
Oliver Alan Kannape
Henrique Galvan Debarba
  • Fonction : Auteur
Mariia Kaliuzhna
  • Fonction : Auteur
Maude Schneider
  • Fonction : Auteur
Stephan Eliez
Olaf Blanke
  • Fonction : Auteur
  • PersonId : 1074634

Résumé

Schizophrenia is a chronic and disabling mental illness characterized by a disordered sense of self. Current theories suggest that deficiencies in the sense of control over one’s actions (Sense of Agency, SoA) may underlie some of the symptoms of schizophrenia. However, it is not clear if agency deficits are a precursor or a result of psychosis. Here, we investigated full body agency using virtual reality in a cohort of 22q11 deletion syndrome participants with a genetic propensity for schizophrenia. In two experiments employing virtual reality, full body motion tracking, and online feedback, we investigated SoA in two separate domains. Our results show that participants with 22q11DS had a considerable deficit in monitoring their actions, compared to age-matched controls in both the temporal and spatial domain. This was coupled with a bias toward erroneous attribution of actions to the self. These results indicate that nonpsychotic 22q11DS participants have a domain general deficit in the conscious sensorimotor mechanisms underlying the bodily self. Our data reveal an abnormality in the SoA in a cohort with a genetic predisposition for schizophrenia, but without psychosis, providing evidence that deficits in delineation of the self may be a precursor rather than a result of the psychotic state.
Fichier principal
Vignette du fichier
reprint_Schizbull2021b.pdf (1.63 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-03514589 , version 1 (06-01-2022)

Identifiants

Citer

Roy Salomon, Oliver Alan Kannape, Henrique Galvan Debarba, Mariia Kaliuzhna, Maude Schneider, et al.. Agency Deficits in a Human Genetic Model of Schizophrenia: Insights From 22q11DS Patients. Schizophrenia Bulletin, 2021, ⟨10.1093/schbul/sbab143⟩. ⟨hal-03514589⟩
25 Consultations
28 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More