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Article Dans Une Revue New Phytologist Année : 2021

Ecological generalism drives hyperdiversity of secondary metabolite gene clusters in xylarialean endophytes

Mario Franco
Jennifer Wisecaver
a Elizabeth Arnold
  • Fonction : Auteur
Yu-Ming Ju
  • Fonction : Auteur
Jason Slot
Lillian Moore
  • Fonction : Auteur
Katharine Eastman
Kelsey Scott
Zachary Konkel
  • Fonction : Auteur
Stephen Mondo
  • Fonction : Auteur
Alan Kuo
Richard Hayes
Sajeet Haridas
Bill Andreopoulos
  • Fonction : Auteur
Robert Riley
  • Fonction : Auteur
Kurt Labutti
Jasmyn Pangilinan
  • Fonction : Auteur
Anna Lipzen
Mojgan Amirebrahimi
  • Fonction : Auteur
Juying Yan
  • Fonction : Auteur
Catherine Adam
  • Fonction : Auteur
Keykhosrow Keymanesh
  • Fonction : Auteur
Vivian Ng
Katherine Louie
  • Fonction : Auteur
Trent Northen
  • Fonction : Auteur
Huei-Mei Hsieh
  • Fonction : Auteur
Ken Youens-Clark
  • Fonction : Auteur
François Lutzoni
Jolanta Miadlikowska
Daniel Eastwood
Richard Hamelin
  • Fonction : Auteur
Igor Grigoriev
Jana U'Ren
  • Fonction : Auteur
A. Elizabeth Arnold
Yu‐ming Ju
Huei‐mei Hsieh
Ken Youens‐clark
Jana U’ren

Résumé

Although secondary metabolites are typically associated with competitive or pathogenic interactions, the high bioactivity of endophytic fungi in the Xylariales, coupled with their abundance and broad host ranges spanning all lineages of land plants and lichens, suggests that enhanced secondary metabolism might facilitate symbioses with phylogenetically diverse hosts. Here, we examined secondary metabolite gene clusters (SMGCs) across 96 Xylariales genomes in two clades (Xylariaceae s.l. and Hypoxylaceae), including 88 newly sequenced genomes of endophytes and closely related saprotrophs and pathogens. We paired genomic data with extensive metadata on endophyte hosts and substrates, enabling us to examine genomic factors related to the breadth of symbiotic interactions and ecological roles. All genomes contain hyperabundant SMGCs; however, Xylariaceae have increased numbers of gene duplications, horizontal gene transfers (HGTs) and SMGCs. Enhanced metabolic diversity of endophytes is associated with a greater diversity of hosts and increased capacity for lignocellulose decomposition. Our results suggest that, as host and substrate generalists, Xylariaceae endophytes experience greater selection to diversify SMGCs compared with more ecologically specialised Hypoxylaceae species. Overall, our results provide new evidence that SMGCs may facilitate symbiosis with phylogenetically diverse hosts, highlighting the importance of microbial symbioses to drive fungal metabolic diversity.

Dates et versions

hal-03508718 , version 1 (03-01-2022)

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Mario Franco, Jennifer Wisecaver, a Elizabeth Arnold, Yu-Ming Ju, Jason Slot, et al.. Ecological generalism drives hyperdiversity of secondary metabolite gene clusters in xylarialean endophytes. New Phytologist, 2021, ⟨10.1111/nph.17873⟩. ⟨hal-03508718⟩
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