Species-selective targeting of pathogens revealed by the atypical structure and active site of Trypanosoma cruzi histone deacetylase DAC2
Abstract
Highlights d Trypanosome histone deacetylases (HDACs) significantly diverge from human HDACs d T. cruzi class I HDACs tcDAC1 and tcDAC2 are essential to the parasite viability d tcDAC2 deacetylase activity can be inhibited by targeting its atypical active site d T. cruzi parasites can be targeted through a tcDAC2-specific inhibitor
Domains
Life Sciences [q-bio]
Origin : Publisher files allowed on an open archive