Species-selective targeting of pathogens revealed by the atypical structure and active site of Trypanosoma cruzi histone deacetylase DAC2 - Archive ouverte HAL Access content directly
Journal Articles Cell Reports Year : 2021

Species-selective targeting of pathogens revealed by the atypical structure and active site of Trypanosoma cruzi histone deacetylase DAC2

Gisele F A Picchi-Constante
  • Function : Author
Theresa Bayer
  • Function : Author
Carina Norström
  • Function : Author
Policarpo A Sales-Junior
  • Function : Author
Eloise P Guerra-Slompo
  • Function : Author
Kristin Hausmann
Tajith B Shaik
Annika Merz
  • Function : Author
Edouard Troesch
  • Function : Author
Karin Schmidtkunz
  • Function : Author
Samuel Goldenberg
  • Function : Author
Raymond J Pierce
  • Function : Author
Marina M Mourão
  • Function : Author
Manfred Jung
  • Function : Author
Johan Schultz
  • Function : Author
Wolfgang Sippl
Nilson I T Zanchin
  • Function : Author
  • PersonId : 1065894
Christophe Romier

Abstract

Highlights d Trypanosome histone deacetylases (HDACs) significantly diverge from human HDACs d T. cruzi class I HDACs tcDAC1 and tcDAC2 are essential to the parasite viability d tcDAC2 deacetylase activity can be inhibited by targeting its atypical active site d T. cruzi parasites can be targeted through a tcDAC2-specific inhibitor
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Dates and versions

hal-03504175 , version 1 (28-12-2021)

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Martin Marek, Elizabeth Ramos-Morales, Gisele F A Picchi-Constante, Theresa Bayer, Carina Norström, et al.. Species-selective targeting of pathogens revealed by the atypical structure and active site of Trypanosoma cruzi histone deacetylase DAC2. Cell Reports, 2021, 37, ⟨10.1016/j.celrep.2021.110129⟩. ⟨hal-03504175⟩
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