<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-03493422</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-09T05:16:47+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Twice- or Once-Daily Dosing of Direct Oral Anticoagulants, a systematic review and meta-analysis</title>
            <author role="crp">
              <persName>
                <forename type="first">S.</forename>
                <surname>Mainbourg</surname>
              </persName>
              <email type="md5">0062608954d20cc2c7a892f274b643b0</email>
              <email type="domain">chu-lyon.fr</email>
              <idno type="idhal" notation="string">sabine-mainbourg</idno>
              <idno type="idhal" notation="numeric">1386840</idno>
              <idno type="halauthorid" notation="string">1626026-1386840</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-4564-2931</idno>
              <affiliation ref="#struct-10025"/>
              <affiliation ref="#struct-353860"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">M.</forename>
                <surname>Cucherat</surname>
              </persName>
              <idno type="halauthorid">234601-0</idno>
              <affiliation ref="#struct-10025"/>
              <affiliation ref="#struct-300074"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">S.</forename>
                <surname>Provencher</surname>
              </persName>
              <idno type="halauthorid">432538-0</idno>
              <affiliation ref="#struct-93488"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">L.</forename>
                <surname>Bertoletti</surname>
              </persName>
              <email type="md5">bfaa5162664bca74b6e7d69150fd4f8a</email>
              <email type="domain">gmail.com</email>
              <idno type="idhal" notation="string">laurent-bertoletti</idno>
              <idno type="idhal" notation="numeric">766136</idno>
              <idno type="halauthorid" notation="string">560933-766136</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-8214-3010</idno>
              <idno type="IDREF">https://www.idref.fr/116915854</idno>
              <affiliation ref="#struct-51335"/>
              <affiliation ref="#struct-2627"/>
              <affiliation ref="#struct-453061"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">P.</forename>
                <surname>Nony</surname>
              </persName>
              <idno type="halauthorid">422717-0</idno>
              <affiliation ref="#struct-10025"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">F.</forename>
                <surname>Gueyffier</surname>
              </persName>
              <email type="md5">b866f0ccd9e43f89f088808b33e8e560</email>
              <email type="domain">univ-lyon1.fr</email>
              <idno type="idhal" notation="string">francois-gueyffier</idno>
              <idno type="idhal" notation="numeric">178661</idno>
              <idno type="halauthorid" notation="string">422624-178661</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-9921-0977</idno>
              <idno type="IDREF">https://www.idref.fr/091433061</idno>
              <affiliation ref="#struct-10025"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">P.</forename>
                <surname>Mismetti</surname>
              </persName>
              <email type="md5">c18b04a764580cfde71e69b539ada590</email>
              <email type="domain">chu-st-etienne.fr</email>
              <idno type="idhal" notation="string">mismpatr</idno>
              <idno type="idhal" notation="numeric">1512792</idno>
              <idno type="halauthorid" notation="string">423603-1512792</idno>
              <affiliation ref="#struct-51335"/>
              <affiliation ref="#struct-2627"/>
              <affiliation ref="#struct-453061"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">C.</forename>
                <surname>Grange</surname>
              </persName>
              <idno type="halauthorid">1405263-0</idno>
              <affiliation ref="#struct-353860"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">I.</forename>
                <surname>Durieu</surname>
              </persName>
              <email type="md5">f1fd76e48642a32551adae840475f5ca</email>
              <email type="domain">chu-lyon.fr</email>
              <idno type="idhal" notation="numeric">1362869</idno>
              <idno type="halauthorid" notation="string">392102-1362869</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-3874-5580</idno>
              <affiliation ref="#struct-353860"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">R.</forename>
                <surname>Kilo</surname>
              </persName>
              <idno type="halauthorid">2383221-0</idno>
              <affiliation ref="#struct-10025"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">S.</forename>
                <surname>Laporte</surname>
              </persName>
              <email type="md5">ad9873a0243c71f549def6dbab479289</email>
              <email type="domain">chu-st-etienne.fr</email>
              <idno type="idhal" notation="string">silvy-laporte</idno>
              <idno type="idhal" notation="numeric">762012</idno>
              <idno type="halauthorid" notation="string">234315-762012</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-6197-8668</idno>
              <idno type="IDREF">https://www.idref.fr/160541662</idno>
              <affiliation ref="#struct-51335"/>
              <affiliation ref="#struct-453061"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">G.</forename>
                <surname>Grenet</surname>
              </persName>
              <idno type="halauthorid">197-0</idno>
              <affiliation ref="#struct-10025"/>
              <affiliation ref="#struct-300074"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">J.-C.</forename>
                <surname>Lega</surname>
              </persName>
              <idno type="halauthorid">432535-0</idno>
              <affiliation ref="#struct-10025"/>
              <affiliation ref="#struct-353860"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Accord Elsevier</forename>
                <surname>CCSD</surname>
              </persName>
              <email type="md5">3cc0cc7b8e3329bfb7423fa2578d788e</email>
              <email type="domain">ccsd.cnrs.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2022-11-07 11:23:49</date>
              <date type="whenModified">2026-04-28 09:18:03</date>
              <date type="whenReleased">2022-11-07 11:23:51</date>
              <date type="whenProduced">2021-01-31</date>
              <date type="whenEndEmbargoed">2021-11-06</date>
              <ref type="file" target="https://hal.science/hal-03493422v1/document">
                <date notBefore="2021-11-06"/>
              </ref>
              <ref type="file" subtype="author" n="1" target="https://hal.science/hal-03493422v1/file/S0049384820305557.pdf" id="file-3841837-3360264">
                <date notBefore="2021-11-06"/>
              </ref>
              <ref type="externalLink" target="http://manuscript.elsevier.com/S0049384820305557/pdf/S0049384820305557.pdf"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="1081876">
                <persName>
                  <forename>Accord Elsevier</forename>
                  <surname>CCSD</surname>
                </persName>
                <email type="md5">3cc0cc7b8e3329bfb7423fa2578d788e</email>
                <email type="domain">ccsd.cnrs.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-03493422</idno>
            <idno type="halUri">https://hal.science/hal-03493422</idno>
            <idno type="halBibtex">mainbourg:hal-03493422</idno>
            <idno type="halRefHtml">&lt;i&gt;Thrombosis Research&lt;/i&gt;, 2021, 197, pp.24 - 32. &lt;a target="_blank" href="https://dx.doi.org/10.1016/j.thromres.2020.10.011"&gt;&amp;#x27E8;10.1016/j.thromres.2020.10.011&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Thrombosis Research, 2021, 197, pp.24 - 32. &amp;#x27E8;10.1016/j.thromres.2020.10.011&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://creativecommons.org/licenses/by-nc/4.0/">CC BY-NC 4.0 - Attribution - Non-commercial use<ref corresp="#file-3841837-3360264"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno>
            <idno type="stamp" n="UNIV-ST-ETIENNE">Université Jean Monnet - Saint-Etienne</idno>
            <idno type="stamp" n="HCL">Hospices Civils de Lyon</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-LYON1">Université Claude Bernard - Lyon I</idno>
            <idno type="stamp" n="CHLS" corresp="HCL">Centre Hospitalier Lyon Sud</idno>
            <idno type="stamp" n="LBBE" corresp="UNIV-LYON1">Laboratoire de biométrie et biologie évolutive </idno>
            <idno type="stamp" n="UDL">UDL</idno>
            <idno type="stamp" n="UNIV-LYON">Université de Lyon</idno>
            <idno type="stamp" n="INSTITUTS-TELECOM">composantes instituts telecom </idno>
            <idno type="stamp" n="TEST-HALCNRS">Collection test HAL CNRS</idno>
            <idno type="stamp" n="ELSEVIER">Import Elsevier</idno>
            <idno type="stamp" n="TEST3-HALCNRS">TEST3-HALCNRS</idno>
            <idno type="stamp" n="TEST4-HALCNRS">collection test</idno>
            <idno type="stamp" n="TEST5-HALCNRS">collection test 5</idno>
            <idno type="stamp" n="INEE-CNRS">Institut écologie et environnement du CNRS</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Twice- or Once-Daily Dosing of Direct Oral Anticoagulants, a systematic review and meta-analysis</title>
                <author role="crp">
                  <persName>
                    <forename type="first">S.</forename>
                    <surname>Mainbourg</surname>
                  </persName>
                  <email type="md5">0062608954d20cc2c7a892f274b643b0</email>
                  <email type="domain">chu-lyon.fr</email>
                  <idno type="idhal" notation="string">sabine-mainbourg</idno>
                  <idno type="idhal" notation="numeric">1386840</idno>
                  <idno type="halauthorid" notation="string">1626026-1386840</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-4564-2931</idno>
                  <affiliation ref="#struct-10025"/>
                  <affiliation ref="#struct-353860"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">M.</forename>
                    <surname>Cucherat</surname>
                  </persName>
                  <idno type="halauthorid">234601-0</idno>
                  <affiliation ref="#struct-10025"/>
                  <affiliation ref="#struct-300074"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">S.</forename>
                    <surname>Provencher</surname>
                  </persName>
                  <idno type="halauthorid">432538-0</idno>
                  <affiliation ref="#struct-93488"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">L.</forename>
                    <surname>Bertoletti</surname>
                  </persName>
                  <email type="md5">bfaa5162664bca74b6e7d69150fd4f8a</email>
                  <email type="domain">gmail.com</email>
                  <idno type="idhal" notation="string">laurent-bertoletti</idno>
                  <idno type="idhal" notation="numeric">766136</idno>
                  <idno type="halauthorid" notation="string">560933-766136</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-8214-3010</idno>
                  <idno type="IDREF">https://www.idref.fr/116915854</idno>
                  <affiliation ref="#struct-51335"/>
                  <affiliation ref="#struct-2627"/>
                  <affiliation ref="#struct-453061"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">P.</forename>
                    <surname>Nony</surname>
                  </persName>
                  <idno type="halauthorid">422717-0</idno>
                  <affiliation ref="#struct-10025"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">F.</forename>
                    <surname>Gueyffier</surname>
                  </persName>
                  <email type="md5">b866f0ccd9e43f89f088808b33e8e560</email>
                  <email type="domain">univ-lyon1.fr</email>
                  <idno type="idhal" notation="string">francois-gueyffier</idno>
                  <idno type="idhal" notation="numeric">178661</idno>
                  <idno type="halauthorid" notation="string">422624-178661</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-9921-0977</idno>
                  <idno type="IDREF">https://www.idref.fr/091433061</idno>
                  <affiliation ref="#struct-10025"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">P.</forename>
                    <surname>Mismetti</surname>
                  </persName>
                  <email type="md5">c18b04a764580cfde71e69b539ada590</email>
                  <email type="domain">chu-st-etienne.fr</email>
                  <idno type="idhal" notation="string">mismpatr</idno>
                  <idno type="idhal" notation="numeric">1512792</idno>
                  <idno type="halauthorid" notation="string">423603-1512792</idno>
                  <affiliation ref="#struct-51335"/>
                  <affiliation ref="#struct-2627"/>
                  <affiliation ref="#struct-453061"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">C.</forename>
                    <surname>Grange</surname>
                  </persName>
                  <idno type="halauthorid">1405263-0</idno>
                  <affiliation ref="#struct-353860"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">I.</forename>
                    <surname>Durieu</surname>
                  </persName>
                  <email type="md5">f1fd76e48642a32551adae840475f5ca</email>
                  <email type="domain">chu-lyon.fr</email>
                  <idno type="idhal" notation="numeric">1362869</idno>
                  <idno type="halauthorid" notation="string">392102-1362869</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-3874-5580</idno>
                  <affiliation ref="#struct-353860"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">R.</forename>
                    <surname>Kilo</surname>
                  </persName>
                  <idno type="halauthorid">2383221-0</idno>
                  <affiliation ref="#struct-10025"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">S.</forename>
                    <surname>Laporte</surname>
                  </persName>
                  <email type="md5">ad9873a0243c71f549def6dbab479289</email>
                  <email type="domain">chu-st-etienne.fr</email>
                  <idno type="idhal" notation="string">silvy-laporte</idno>
                  <idno type="idhal" notation="numeric">762012</idno>
                  <idno type="halauthorid" notation="string">234315-762012</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-6197-8668</idno>
                  <idno type="IDREF">https://www.idref.fr/160541662</idno>
                  <affiliation ref="#struct-51335"/>
                  <affiliation ref="#struct-453061"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">G.</forename>
                    <surname>Grenet</surname>
                  </persName>
                  <idno type="halauthorid">197-0</idno>
                  <affiliation ref="#struct-10025"/>
                  <affiliation ref="#struct-300074"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">J.-C.</forename>
                    <surname>Lega</surname>
                  </persName>
                  <idno type="halauthorid">432535-0</idno>
                  <affiliation ref="#struct-10025"/>
                  <affiliation ref="#struct-353860"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">19628</idno>
                <idno type="issn">0049-3848</idno>
                <idno type="eissn">1879-2472</idno>
                <title level="j">Thrombosis Research</title>
                <imprint>
                  <publisher>Elsevier</publisher>
                  <biblScope unit="volume">197</biblScope>
                  <biblScope unit="pp">24 - 32</biblScope>
                  <date type="datePub">2021-01-31</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1016/j.thromres.2020.10.011</idno>
              <idno type="pii">S0049-3848(20)30555-7</idno>
              <idno type="pubmed">33161284</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">Direct oral anticoagulant</term>
                <term xml:lang="en">Dosing regimen</term>
                <term xml:lang="en">Major bleeding</term>
                <term xml:lang="en">Meta-analysis</term>
                <term xml:lang="en">Risk of thrombosis</term>
                <term xml:lang="en">Direct oral anticoagulant</term>
                <term xml:lang="en">Direct oral anticoagulant</term>
                <term xml:lang="en">Direct oral anticoagulant</term>
              </keywords>
              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Aim: The direct oral anticoagulants (DOAC) have similar half-lives, but the dosing regimen varies between once daily (QD) or twice daily (BID). For some prescribers, the QD regimen improves compliance. Others prefer BID regimens to promote better stability of plasma concentrations, particularly in the event of missed doses. Limited level of evidence provides guidance about the best treatment strategy. The purpose of this study was to compare the treatment effect of QD vs. BID administration of DOACs in major orthopedic surgery (MOS), non-valvular atrial fibrillation (NVAF), venous thromboembolism (VTE), and acute coronary syndrome (ACS).Methods: We conducted a systematic review up to April 2020. We included phase II clinical trials comparing DOAC QD vs BID with same daily dose. We extracted data for the occurrence of major thrombosis (proximal deep vein thrombosis, pulmonary embolism, myocardial infarction, ischemic stroke) and major hemorrhage (ISTH criteria and recommendations of the European Medicines Agency for surgical patients). Relative risks (RR) were combined using a fixed and random effects weighted meta-analysis.Results: Twelve randomized, controlled, phase II trials were included (10,716 patients), representing 24 dosing regimen comparisons of apixaban, darexaban, edoxaban, rivaroxaban, letaxaban, and dabigatran. There was no difference for major thrombotic event (RRBID/QD = 1.06, 95%IC 0.86-1.30) nor for major bleeding (RRBID/QD = 1.02, 95%IC 0.84-1.23) between the BID vs QD regimens, without heterogeneity (I2 = 0%).Conclusion: Our study does not support a global difference in term of efficacy and safety of the BID and QD regimens of DOAC in MOS, NVAF, VTE and ACS.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-10025" status="VALID">
          <idno type="IdRef">15069671X</idno>
          <idno type="ISNI">0000000403863493</idno>
          <idno type="RNSR">199411998X</idno>
          <idno type="ROR">https://ror.org/03skt0t88</idno>
          <orgName>Laboratoire de Biométrie et Biologie Evolutive - UMR 5558</orgName>
          <orgName type="acronym">LBBE</orgName>
          <date type="start">1995-01-01</date>
          <desc>
            <address>
              <addrLine>43 Bld du 11 Novembre 1918 69622 VILLEURBANNE CEDEX</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://lbbe.univ-lyon1.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-194495" type="direct"/>
            <relation active="#struct-301088" type="indirect"/>
            <relation active="#struct-301767" type="direct"/>
            <relation name="UMR5558" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-353860" status="VALID">
          <idno type="ROR">https://ror.org/023xgd207</idno>
          <orgName>Centre Hospitalier Lyon Sud [CHU - HCL]</orgName>
          <orgName type="acronym">CHLS</orgName>
          <desc>
            <address>
              <addrLine>165 Chemin du Grand Revoyet69495 Pierre-Bénite</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-lyon.fr/fr/centre-hospitalier-lyon-sud</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300074" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-300074" status="VALID">
          <idno type="IdRef">026534657</idno>
          <idno type="ROR">https://ror.org/01502ca60</idno>
          <orgName>Hospices Civils de Lyon</orgName>
          <orgName type="acronym">HCL</orgName>
          <desc>
            <address>
              <addrLine>3 Quai des Célestins69002 Lyon</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-lyon.fr/fr/hospices-civils-de-lyon-hcl</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-93488" status="VALID">
          <idno type="IdRef">028035747</idno>
          <idno type="ISNI">0000000419368390</idno>
          <idno type="ROR">https://ror.org/04sjchr03</idno>
          <idno type="Wikidata">Q1067935</idno>
          <orgName>Université Laval [Québec]</orgName>
          <orgName type="acronym">ULaval</orgName>
          <desc>
            <address>
              <addrLine>2325, rue de l'Université Québec G1V 0A6</addrLine>
              <country key="CA"/>
            </address>
            <ref type="url">https://www.ulaval.ca/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-51335" status="VALID">
          <idno type="IdRef">250789094</idno>
          <idno type="ROR">https://ror.org/04pn6vp43</idno>
          <orgName>Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne]</orgName>
          <orgName type="acronym">CHU ST-E</orgName>
          <date type="start">1972-10-30</date>
          <desc>
            <address>
              <addrLine>42055 Saint Etienne cedex 2</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-st-etienne.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-1327915" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-2627" status="VALID">
          <idno type="RNSR">200320132Z</idno>
          <orgName>Centre d'Investigation Clinique - Epidémiologie Clinique [CHU Saint-Etienne]</orgName>
          <orgName type="acronym">CIC-EC 1408</orgName>
          <date type="start">2003-01-01</date>
          <desc>
            <address>
              <addrLine>Hôpital Nord 120, Avenue Albert Raimond - Bât. Recherche - 42055 Saint-Etienne Cedex 2</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-st-etienne.fr/Professionnels/Recherche/Presentation_DRCI/Pro_CIC_EC.asp</ref>
          </desc>
          <listRelation>
            <relation active="#struct-51335" type="direct"/>
            <relation active="#struct-1327915" type="indirect"/>
            <relation active="#struct-300284" type="direct"/>
            <relation name="CIE3" active="#struct-303623" type="direct"/>
          </listRelation>
        </org>
        <org type="department" xml:id="struct-453061" status="VALID">
          <idno type="IdRef">234812249</idno>
          <idno type="RNSR">201622149K</idno>
          <orgName>Santé Ingénierie Biologie Saint-Etienne</orgName>
          <orgName type="acronym">SAINBIOSE</orgName>
          <date type="start">2016-01-01</date>
          <desc>
            <address>
              <addrLine>Faculté de Médecine - campus Santé Innovations10 rue de la Marandinière 42270 Saint Priest-en-Jarez</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://sainbiose.univ-st-etienne.fr/fr/index.html</ref>
          </desc>
          <listRelation>
            <relation active="#struct-22135" type="direct"/>
            <relation active="#struct-29212" type="indirect"/>
            <relation active="#struct-302102" type="indirect"/>
            <relation active="#struct-300284" type="direct"/>
            <relation active="#struct-1327915" type="indirect"/>
            <relation name="U1059" active="#struct-303623" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-194495" status="VALID">
          <idno type="IdRef">026402823</idno>
          <idno type="ISNI">0000000121686185</idno>
          <idno type="ROR">https://ror.org/029brtt94</idno>
          <orgName>Université Claude Bernard Lyon 1</orgName>
          <orgName type="acronym">UCBL</orgName>
          <desc>
            <address>
              <addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-lyon1.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-301088" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-301088" status="VALID">
          <idno type="ROR">https://ror.org/01rk35k63</idno>
          <orgName>Université de Lyon</orgName>
          <desc>
            <address>
              <addrLine>92 rue Pasteur - CS 30122, 69361 Lyon Cedex 07</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.universite-lyon.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-301767" status="VALID">
          <idno type="ROR">https://ror.org/01c7wz417</idno>
          <orgName>VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement</orgName>
          <orgName type="acronym">VAS</orgName>
          <date type="start">2010-01-01</date>
          <desc>
            <address>
              <addrLine>Université de Lyon, VetAgro Sup, 69280 Marcy l'Etoile (campus vétérinaire); Université de Clermont, VetAgro Sup, 63370 Lempdes (campus agronomique)</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.vetagro-sup.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-1327915" status="VALID">
          <idno type="IdRef">285395831</idno>
          <orgName>Université Jean Monnet (EPSCPE)</orgName>
          <orgName type="acronym">UJM EPE</orgName>
          <date type="start">2025-01-01</date>
          <desc>
            <address>
              <addrLine>10 rue Tréfilerie42100 Saint-Etienne</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-st-etienne.fr/fr/index.html</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300284" status="VALID">
          <idno type="IdRef">028209966</idno>
          <idno type="ISNI">0000 0001 2158 1682</idno>
          <idno type="ROR">https://ror.org/04yznqr36</idno>
          <idno type="Wikidata">Q623154</idno>
          <orgName>Université Jean Monnet - Saint-Étienne</orgName>
          <orgName type="acronym">UJM</orgName>
          <date type="start">1969-03-27</date>
          <date type="end">2025-01-01</date>
          <desc>
            <address>
              <addrLine>10, Rue Tréfilerie – CS 8230142023 Saint-Étienne Cedex 2</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-st-etienne.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-1327915" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-22135" status="VALID">
          <orgName>Centre Ingénierie et Santé</orgName>
          <orgName type="acronym">CIS-ENSMSE</orgName>
          <desc>
            <address>
              <addrLine>158, cours Fauriel F-42023 Saint-Étienne cedex 2</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.emse.fr/spip/-CIS-.html</ref>
          </desc>
          <listRelation>
            <relation active="#struct-29212" type="direct"/>
            <relation active="#struct-302102" type="indirect"/>
          </listRelation>
        </org>
        <org type="regrouplaboratory" xml:id="struct-29212" status="VALID">
          <orgName>École des Mines de Saint-Étienne</orgName>
          <orgName type="acronym">Mines Saint-Étienne MSE</orgName>
          <desc>
            <address>
              <addrLine>158, Cours Fauriel - 42023 Saint Étienne cedex 2</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.mines-stetienne.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-302102" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-302102" status="VALID">
          <idno type="IdRef">192427156</idno>
          <idno type="ISNI">000000012202567X</idno>
          <idno type="ROR">https://ror.org/025vp2923</idno>
          <idno type="Wikidata">Q27962533</idno>
          <orgName>Institut Mines-Télécom [Paris]</orgName>
          <orgName type="acronym">IMT</orgName>
          <date type="start">2012-03-01</date>
          <desc>
            <address>
              <addrLine>19 Place Marguerite Perey, 91120 Palaiseau</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.imt.fr/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>