Journal Articles International Journal of Antimicrobial Agents Year : 2020

Voriconazole topical cream formulation: evidence for stability and antifungal activity

Fabrice Vidal
  • Function : Author
  • PersonId : 1337529
Joël Schlatter

Abstract

Systemic use of voriconazole (VCZ) might be restricted by adverse events, such as hepatotoxicity and neurotoxicity, or drug-drug interactions. Topical VCZ application to skin may help to treat local infection more effectively and limit unwanted whole-body exposure. Topical VCZ cream was stable for 90 days when refrigerated. A patient with cutaneous Fusarium solani infection on his right forearm was successfully treated with topical 1% VCZ cream after failure of oral VCZ treatment.

Fichier principal
Vignette du fichier
S0924857920302533.pdf (419.75 Ko) Télécharger le fichier
Origin Files produced by the author(s)
Licence

Dates and versions

hal-03492491 , version 1 (30-08-2022)

Licence

Identifiers

Cite

Camille Bouchand, David Nguyen, Philippe-Henri Secretan, Fabrice Vidal, Romain Guery, et al.. Voriconazole topical cream formulation: evidence for stability and antifungal activity. International Journal of Antimicrobial Agents, 2020, 56 (3), pp.106083. ⟨10.1016/j.ijantimicag.2020.106083⟩. ⟨hal-03492491⟩
283 View
479 Download

Altmetric

Share

  • More