The specific role of the striatum in interval timing: The Huntington’s disease model - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Neuroimage-Clinical Année : 2021

The specific role of the striatum in interval timing: The Huntington’s disease model

Résumé

Time processing over intervals of hundreds of milliseconds to minutes, also known as interval timing, is associated with the striatum. Huntington's disease patients (HD) with striatal degeneration have impaired interval timing, but the extent and specificity of these deficits remain unclear. Are they specific to the temporal domain, or do they extend to the spatial domain too? Do they extend to both the perception and production of interval timing? Do they appear before motor symptoms in Huntington's disease (Pre-HD)? We addressed these issues by assessing both temporal abilities (in the seconds range) and spatial abilities (in the cm range) in 20 Pre-HD, 25 HD patients, and 25 healthy Controls, in discrimination, bisection and production paradigms. In addition, all participants completed a questionnaire assessing temporal and spatial disorientation in daily life, and the gene carriers (i.e., HD and Pre-HD participants) underwent structural brain MRI. Overall, HD patients were more impaired in the temporal than in the spatial domain in the behavioral tasks, and expressed a greater disorientation in the temporal domain in the daily life questionnaire. In contrast, Pre-HD participants showed no sign of a specific temporal deficit. Furthermore, MRI analyses indicated that performances in the temporal discrimination task were associated with a larger striatal grey matter volume in the striatum in gene carriers. Altogether, behavioral, brain imaging and questionnaire data support the hypothesis that the striatum is a specific component of interval timing processes. Evaluations of temporal disorientation and interval timing processing could be used as clinical tools for HD patients.

Domaines

Psychologie
Fichier principal
Vignette du fichier
Lemoine-2021.pdf (2.86 Mo) Télécharger le fichier
Origine : Publication financée par une institution

Dates et versions

hal-03490594 , version 1 (17-12-2021)

Licence

Paternité - Pas d'utilisation commerciale - Pas de modification

Identifiants

Citer

Laurie Lemoine, Marine Lunven, Blanche Bapst, Laurent Cleret de Langavant, Vincent de Gardelle, et al.. The specific role of the striatum in interval timing: The Huntington’s disease model. Neuroimage-Clinical, 2021, 32, pp.102865. ⟨10.1016/j.nicl.2021.102865⟩. ⟨hal-03490594⟩
41 Consultations
51 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More