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Article Dans Une Revue Journal of Neuroscience Methods Année : 2019

New software dedicated to virtual mazes for human cognitive investigations

Résumé

Background: Compared to previous neuropsychological investigations with standard paper-pen tests limited to test complex spatial learning and memory processes, 3-D virtual immersive technology might offer new tools for research purposes and for diagnosis in patients suffering from mild cognitive impairment or dementia. Comparison with existing methods: Current software proposes a customizable VR environment combined with an analyser module based on regions of interest and some parameters of analysis or pre-calibrated VR mazes with raw data. New method: We attempted to create the VRmaze software offering either turnkey mazes with automatic tracking and analysis, or more complex and specific virtual mazes for human brain-behavioural research adaptable to all desired settings and parameters of analysis. The software combines 3D pre-calibrated VR tests or free customizable VR tests with digitized neuropsychological 2D standard and validated tests or tasks. Results: We have tested an ERAM, a MWM and a reverse T-maze on 44 healthy subjects, showing gender differences in terms of navigation strategy. We have observed that the choice of benchmarks, instructions, and experimental parameters influence the performances. Conclusion: VRmaze software offers a translational approach for research units that wish to combine animal models and patient evaluations as well as complex 3D tasks and standardized neuropsychological tests combined with an automatic analysis opening a large perspective in the neurosciences to investigate cognitive functions. A clinical module with preconfigured 2- and 3-D tasks should offer clinicians an easy way to evaluate their patients routinely.
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Dates et versions

hal-03487908 , version 1 (20-07-2022)

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Paternité - Pas d'utilisation commerciale

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M.L. Machado, N. Lefèvre, B. Philoxene, A. Le Gall, S. Madeleine, et al.. New software dedicated to virtual mazes for human cognitive investigations. Journal of Neuroscience Methods, 2019, 327, pp.108388 -. ⟨10.1016/j.jneumeth.2019.108388⟩. ⟨hal-03487908⟩
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