Sgs-3 chromatin structure and trans-activators: developmental and ecdysone induction of a glue enhancer-binding factor, GEBF-I, in Drosophila larvae - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Molecular and Cellular Biology Année : 1991

Sgs-3 chromatin structure and trans-activators: developmental and ecdysone induction of a glue enhancer-binding factor, GEBF-I, in Drosophila larvae

P Georgel
  • Fonction : Auteur
P Ramain
  • Fonction : Auteur
G Dretzen
  • Fonction : Auteur
G Richards
  • Fonction : Auteur
M Bellard
  • Fonction : Auteur

Résumé

The transcription of the Drosophila melanogaster 68C salivary gland glue gene Sgs-3 involves the interaction of a distal and a proximal regulatory region. These are marked in vivo by a specific chromatin structure which is established sequentially during development, starting early in embryogenesis. The distal region is characterized by a stage- and tissue-specific DNase I hypersensitive site. A stage- and tissue-specific factor, GEBF-I, binds in this region and is missing in 2B5 mutant larvae which lack Sgs-3 transcripts. This binding involves the simultaneous interaction with two distinct DNA sequences which induces conformational changes in the protein. Salivary glands acquire competence to respond to ecdysone in the mid-third larval instar, whereafter the hormone rapidly induces both the GEBF-I protein and Sgs-3 transcription.
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hal-03478188 , version 1 (13-12-2021)

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Citer

P Georgel, P Ramain, A Giangrande, G Dretzen, G Richards, et al.. Sgs-3 chromatin structure and trans-activators: developmental and ecdysone induction of a glue enhancer-binding factor, GEBF-I, in Drosophila larvae. Molecular and Cellular Biology, 1991, 11 (1), pp.523-532. ⟨10.1128/mcb.11.1.523-532.1991⟩. ⟨hal-03478188⟩
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