This paper aims to present the development process of clusters in Serbia. The paper analyse also of cluster development strategy in some neighbouring Balkan countries. Regarding the development of industrial production of some Balkan countries, there are also major differences. With the exception of Albania, which was and still is very de-industrialized, and Bosnia and Herzegovina, where we take 1995 as the base year (which is why there has been a rapid growth), other countries are still far from the levels of production in 1990. This is one of the main problems, excepting also economic, political and social aspects and facts, which is developed in this paper.