SHREC 2021: surface-based protein domains retrieval
Florent Langenfeld
,
Tunde Aderinwale
,
Charles Christoffer
,
Woong-Hee Shin
,
Genki Terashi
,
Xiao Wang
,
Daisuke Kihara
,
Halim Benhabiles
(1, 2, 3)
,
Karim Hammoudi
(4)
,
Adnane Cabani
(5, 6)
,
Feryal Windal
(1, 2, 3)
,
Mahmoud Melkemi
(4, 6)
,
Ekpo Otu
,
Reyer Zwiggelaar
,
David Hunter
,
Yonghuai Liu
,
Léa Sirugue
,
H. Nguyen Huu-Nghia
,
H. Nguyen Tuan-Duy
,
Vinh-Thuyen Nguyen–truong
,
Danh Le
,
Hai-Dang Nguyen
,
Minh-Triet Tran
,
Matthieu Montès
1
IEMN -
Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520
2 BIOMEMS - IEMN - Bio-Micro-Electro-Mechanical Systems - IEMN
3 JUNIA - JUNIA
4 IRIMAS - Institut de Recherche en Informatique Mathématiques Automatique Signal - IRIMAS - UR 7499
5 ESIGELEC - École Supérieure d’Ingénieurs en Génie Électrique
6 UNISTRA - Université de Strasbourg
2 BIOMEMS - IEMN - Bio-Micro-Electro-Mechanical Systems - IEMN
3 JUNIA - JUNIA
4 IRIMAS - Institut de Recherche en Informatique Mathématiques Automatique Signal - IRIMAS - UR 7499
5 ESIGELEC - École Supérieure d’Ingénieurs en Génie Électrique
6 UNISTRA - Université de Strasbourg
Florent Langenfeld
- Function : Author
- PersonId : 775402
- ORCID : 0000-0002-3184-3401
Tunde Aderinwale
- Function : Author
Charles Christoffer
- Function : Author
- PersonId : 797465
- ORCID : 0000-0002-6163-6323
Woong-Hee Shin
- Function : Author
- PersonId : 802692
- ORCID : 0000-0003-3462-0243
Genki Terashi
- Function : Author
Xiao Wang
- Function : Author
Daisuke Kihara
- Function : Author
- PersonId : 765070
- ORCID : 0000-0003-4091-6614
- IdRef : 155148435
Halim Benhabiles
- Function : Author
- PersonId : 748527
- IdHAL : halim-benhabiles
- ORCID : 0000-0003-2950-5312
Karim Hammoudi
- Function : Author
- PersonId : 765929
- ORCID : 0000-0002-4804-4796
- IdRef : 159221773
Adnane Cabani
- Function : Author
- PersonId : 177657
- IdHAL : adnane-cabani
- ORCID : 0000-0001-5948-8950
- IdRef : 121294587
Feryal Windal
- Function : Author
- PersonId : 749061
- IdHAL : feryal-windal
Mahmoud Melkemi
- Function : Author
- PersonId : 775568
- ORCID : 0000-0002-9045-9047
Ekpo Otu
- Function : Author
- PersonId : 802078
- ORCID : 0000-0002-5616-6902
Reyer Zwiggelaar
- Function : Author
David Hunter
- Function : Author
- PersonId : 767921
- ORCID : 0000-0002-7625-2461
Yonghuai Liu
- Function : Author
Léa Sirugue
- Function : Author
H. Nguyen Huu-Nghia
- Function : Author
H. Nguyen Tuan-Duy
- Function : Author
Vinh-Thuyen Nguyen–truong
- Function : Author
Danh Le
- Function : Author
Hai-Dang Nguyen
- Function : Author
Minh-Triet Tran
- Function : Author
Matthieu Montès
- Function : Author
Abstract
Proteins are essential to nearly all cellular mechanism, and often interact through their surface with other cell molecules, such as proteins and ligands. The evolution generates plenty of different proteins, with unique abilities, but also proteins with related functions hence surface, which is therefore of primary importance for their activity. In the present work, we assess the ability of five methods to retrieve similar protein surfaces, using either their shape only (3D meshes), or their shape and the electrostatic potential at their surface, an important surface property. Five different groups participated in this challenge using the shape only, and one group extended its pre-existing algorithm to handle the electrostatic potential. The results reveal both the ability of the methods to detect related proteins and their difficulties to distinguish between topologically related proteins.