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              <p>A possible explanation based on first principles for the appearance of the Omicron variant of the SARS-CoV-2 virus is proposedinvolving coinfection with HIV.  The gist is that the resultant HIV-induced immunocompromiseallows SARS-CoV-2 greater latitude to explore its own mutational space.  This latitude is not withoutrestriction, and a specific biophysical constraint isexplored.  Specifically, a nearly two - to fivefold discrepancy in backbone hydrogen bonding is observedbetween sub-molecules in Protein Data Bank files of the spike glycoprotein yielding two conclusions: mutagenic residues in the receptor-binding subunit of the spike much more frequently do not participate in backbone hydrogen bonds;and a technique of viral escape is therefore to remove such bonds within physico-chemical and functional constraints.Earlier work, from which the previous discussion is entirely independent, explains these phenomenafrom general principles of free energy, namely, the metastability of the glycoprotein.  The conclusions therefore likely hold more generally as principles in virology.</p>
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