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Journal Articles Nucleic Acids Research Year : 2022

DisProt in 2022: improved quality and accessibility of protein intrinsic disorder annotation

Rita Pancsa
Lucía B Chemes
Mátyás Pajkos
Tamas Lazar
Samuel Peña-Díaz
Jaime Santos
Veronika Ács
Nazanin Farahi
Erzsébet Fichó
Claudio Bassot
Norman E Davey
Radoslav Davidović
Laszlo Dobson
Arne Elofsson
Gábor Erdős
Juliana Glavina
Valentín Iglesias
Zsófia Kálmán
Matteo Lambrughi
Emiliano Maiani
Julia Marchetti
Attila Mészáros
Marian Novotný
Nicolás Palopoli
Gabriele Pozzati
Vasilis J Promponas
Jordi Pujols
Martin Salas
Eva Schad
Aditi Shenoy
Tamás Szaniszló
Konstantinos D Tsirigos
Nevena Veljkovic
Gustavo Parisi
Salvador Ventura
Zsuzsanna Dosztányi
Peter Tompa

Abstract

The Database of Intrinsically Disordered Proteins (DisProt, URL: https://disprot.org) is the major repository of manually curated annotations of intrinsically disordered proteins and regions from the literature. We report here recent updates of DisProt version 9, including a restyled web interface, refactored Intrinsically Disordered Proteins Ontology (IDPO), improvements in the curation process and significant content growth of around 30%. Higher quality and consistency of annotations is provided by a newly implemented reviewing process and training of curators. The increased curation capacity is fostered by the integration of DisProt with APICURON, a dedicated resource for the proper attribution and recognition of biocuration efforts. Better interoperability is provided through the adoption of the Minimum Information About Disorder (MIADE) standard, an active collaboration with the Gene Ontology (GO) and Evidence and Conclusion Ontology (ECO) consortia and the support of the ELIXIR infrastructure.
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hal-03463975 , version 1 (02-12-2021)

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Attribution - NonCommercial

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Federica Quaglia, Bálint Mészáros, Edoardo Salladini, András Hatos, Rita Pancsa, et al.. DisProt in 2022: improved quality and accessibility of protein intrinsic disorder annotation. Nucleic Acids Research, 2022, 50 (D1), pp.D480-D487. ⟨10.1093/nar/gkab1082⟩. ⟨hal-03463975⟩
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