<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-03463649</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-12T22:17:20+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Dual-energy CT hybridation and kernel processing effects on the estimation of bone mineral mass and density: a calcination study on ex vivo human femur</title>
            <author role="aut">
              <persName>
                <forename type="first">Philippe Paul</forename>
                <surname>Wagner</surname>
              </persName>
              <idno type="halauthorid">2359041-0</idno>
              <affiliation ref="#struct-139725"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jean-Paul</forename>
                <surname>Roux</surname>
              </persName>
              <idno type="halauthorid">136736-0</idno>
              <affiliation ref="#struct-139725"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Quentin</forename>
                <surname>Chuzel</surname>
              </persName>
              <idno type="halauthorid">2359042-0</idno>
              <affiliation ref="#struct-300094"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Pawel</forename>
                <surname>Szulc</surname>
              </persName>
              <idno type="halauthorid">1372815-0</idno>
              <affiliation ref="#struct-139725"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">François</forename>
                <surname>Bermond</surname>
              </persName>
              <email type="md5">a9ece7d6b660bc1db75ecff946dc8790</email>
              <email type="domain">univ-eiffel.fr</email>
              <ptr type="url" target="https://pagespro.univ-gustave-eiffel.fr/francois-bermond"/>
              <idno type="idhal" notation="string">franccois-bermond</idno>
              <idno type="idhal" notation="numeric">9946</idno>
              <idno type="halauthorid" notation="string">20083-9946</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/O-4195-2016</idno>
              <idno type="IDREF">https://www.idref.fr/056873670</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-4979-4097</idno>
              <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?hl=fr&amp;user=P54mqFQAAAAJ</idno>
              <affiliation ref="#struct-581164"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">François</forename>
                <surname>Duboeuf</surname>
              </persName>
              <idno type="halauthorid">313195-0</idno>
              <affiliation ref="#struct-139725"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Roland</forename>
                <surname>Chapurlat</surname>
              </persName>
              <email type="md5">e0da1f484575e71dd9393f3aeaafe571</email>
              <email type="domain">inserm.fr</email>
              <idno type="idhal" notation="numeric">1526090</idno>
              <idno type="halauthorid" notation="string">637673-1526090</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-8214-6385</idno>
              <affiliation ref="#struct-139725"/>
              <affiliation ref="#struct-300094"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Hélène</forename>
                <surname>Follet</surname>
              </persName>
              <idno type="halauthorid">923-0</idno>
              <affiliation ref="#struct-139725"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jean-Baptiste</forename>
                <surname>Pialat</surname>
              </persName>
              <idno type="halauthorid">788760-0</idno>
              <affiliation ref="#struct-139725"/>
              <affiliation ref="#struct-300094"/>
              <affiliation ref="#struct-353860"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Ifsttar</forename>
                <surname>Cadic</surname>
              </persName>
              <email type="md5">ac6d72b766ba563125152d1789e6a340</email>
              <email type="domain">ifsttar.fr</email>
            </editor>
            <funder ref="#projanr-41424"/>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2022-01-03 16:28:44</date>
              <date type="whenWritten">2022-04-01</date>
              <date type="whenModified">2026-05-12 15:56:01</date>
              <date type="whenReleased">2022-01-03 16:28:44</date>
              <date type="whenProduced">2022-04-01</date>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="128222">
                <persName>
                  <forename>Ifsttar</forename>
                  <surname>Cadic</surname>
                </persName>
                <email type="md5">ac6d72b766ba563125152d1789e6a340</email>
                <email type="domain">ifsttar.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-03463649</idno>
            <idno type="halUri">https://hal.science/hal-03463649</idno>
            <idno type="halBibtex">wagner:hal-03463649</idno>
            <idno type="halRefHtml">&lt;i&gt;Osteoporosis International&lt;/i&gt;, 2022, 33 (4), pp.909-920. &lt;a target="_blank" href="https://dx.doi.org/10.1007/s00198-021-06210-z"&gt;&amp;#x27E8;10.1007/s00198-021-06210-z&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Osteoporosis International, 2022, 33 (4), pp.909-920. &amp;#x27E8;10.1007/s00198-021-06210-z&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno>
            <idno type="stamp" n="HCL">Hospices Civils de Lyon</idno>
            <idno type="stamp" n="UNIV-LYON1">Université Claude Bernard - Lyon I</idno>
            <idno type="stamp" n="CHLS" corresp="HCL">Centre Hospitalier Lyon Sud</idno>
            <idno type="stamp" n="HEH" corresp="HCL">Hôpital Edouard Herriot</idno>
            <idno type="stamp" n="PRIMES">Physics, Radiobiology, Medical Imaging, and Simulation (PRIMES)</idno>
            <idno type="stamp" n="PRIMES_WP5" corresp="PRIMES">WP5: Simulation et modélisation d'images</idno>
            <idno type="stamp" n="IFSTTAR">Ifsttar</idno>
            <idno type="stamp" n="LBMC" corresp="UNIV-LYON1">Laboratoire de Biomécanique et Mécanique des Chocs</idno>
            <idno type="stamp" n="UDL">UDL</idno>
            <idno type="stamp" n="UNIV-LYON">Université de Lyon</idno>
            <idno type="stamp" n="ANR">ANR</idno>
            <idno type="stamp" n="UNIV-EIFFEL">Université Gustave Eiffel</idno>
            <idno type="stamp" n="U-EIFFEL">Université Gustave Eiffel</idno>
            <idno type="stamp" n="TS2">Transport, Santé, Sécurité</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="1">Not set</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Dual-energy CT hybridation and kernel processing effects on the estimation of bone mineral mass and density: a calcination study on ex vivo human femur</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Philippe Paul</forename>
                    <surname>Wagner</surname>
                  </persName>
                  <idno type="halauthorid">2359041-0</idno>
                  <affiliation ref="#struct-139725"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jean-Paul</forename>
                    <surname>Roux</surname>
                  </persName>
                  <idno type="halauthorid">136736-0</idno>
                  <affiliation ref="#struct-139725"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Quentin</forename>
                    <surname>Chuzel</surname>
                  </persName>
                  <idno type="halauthorid">2359042-0</idno>
                  <affiliation ref="#struct-300094"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Pawel</forename>
                    <surname>Szulc</surname>
                  </persName>
                  <idno type="halauthorid">1372815-0</idno>
                  <affiliation ref="#struct-139725"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">François</forename>
                    <surname>Bermond</surname>
                  </persName>
                  <email type="md5">a9ece7d6b660bc1db75ecff946dc8790</email>
                  <email type="domain">univ-eiffel.fr</email>
                  <ptr type="url" target="https://pagespro.univ-gustave-eiffel.fr/francois-bermond"/>
                  <idno type="idhal" notation="string">franccois-bermond</idno>
                  <idno type="idhal" notation="numeric">9946</idno>
                  <idno type="halauthorid" notation="string">20083-9946</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/O-4195-2016</idno>
                  <idno type="IDREF">https://www.idref.fr/056873670</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-4979-4097</idno>
                  <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?hl=fr&amp;user=P54mqFQAAAAJ</idno>
                  <affiliation ref="#struct-581164"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">François</forename>
                    <surname>Duboeuf</surname>
                  </persName>
                  <idno type="halauthorid">313195-0</idno>
                  <affiliation ref="#struct-139725"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Roland</forename>
                    <surname>Chapurlat</surname>
                  </persName>
                  <email type="md5">e0da1f484575e71dd9393f3aeaafe571</email>
                  <email type="domain">inserm.fr</email>
                  <idno type="idhal" notation="numeric">1526090</idno>
                  <idno type="halauthorid" notation="string">637673-1526090</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-8214-6385</idno>
                  <affiliation ref="#struct-139725"/>
                  <affiliation ref="#struct-300094"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Hélène</forename>
                    <surname>Follet</surname>
                  </persName>
                  <idno type="halauthorid">923-0</idno>
                  <affiliation ref="#struct-139725"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jean-Baptiste</forename>
                    <surname>Pialat</surname>
                  </persName>
                  <idno type="halauthorid">788760-0</idno>
                  <affiliation ref="#struct-139725"/>
                  <affiliation ref="#struct-300094"/>
                  <affiliation ref="#struct-353860"/>
                </author>
              </analytic>
              <monogr>
                <idno type="localRef">RIS00001913</idno>
                <idno type="halJournalId" status="VALID">17715</idno>
                <idno type="issn">0937-941X</idno>
                <idno type="eissn">1433-2965</idno>
                <title level="j">Osteoporosis International</title>
                <imprint>
                  <publisher>Springer Verlag</publisher>
                  <biblScope unit="volume">33</biblScope>
                  <biblScope unit="issue">4</biblScope>
                  <biblScope unit="pp">909–920</biblScope>
                  <date type="datePub">2022-04-01</date>
                  <date type="dateEpub">2022-04-01</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1007/s00198-021-06210-z</idno>
              <idno type="pubmed">34837503</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">BMD</term>
                <term xml:lang="en">Calcination</term>
                <term xml:lang="en">DXA</term>
                <term xml:lang="en">Dual-energy CT</term>
                <term xml:lang="en">Kernels</term>
                <term xml:lang="en">Spectral imaging.</term>
              </keywords>
              <classCode scheme="halDomain" n="sdv.mhep.rsoa">Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system</classCode>
              <classCode scheme="halDomain" n="sdv.ib.ima">Life Sciences [q-bio]/Bioengineering/Imaging</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Introduction: Recent technological advances with dual-energy quantitative computed tomography (DEQCT) allow to combine two images of different level of energy to obtain simulated mono-energetic images at 60 keV (SIM60KeV-QCT) with improved image contrast in clinical practice. This study includes three topics: (1) compare bone mineral content (BMC), areal and volumetric bone mineral density (aBMD, vBMD) obtained with SIM60KeV-QCT, single-energy QCT (SEQCT), and dual X-ray absorptiometry (DXA); (2) compare ash density and weight with respective vBMD and BMC assessed on SIM60KeV-QCT, SEQCT, and DXA; and (3) compare the influence of reconstruction kernels on the accuracy of vBMD and BMC using ash density and ash weight as the reference values.Methods: DXA, SEQCT, and DEQCT acquisitions were performed ex vivo on 42 human femurs. Standard kernel (SK) and bone kernel (BK) were applied to each stack of images. Ten diaphyses and 10 femoral necks were cut, scanned, and reconstructed using the techniques described above. Finally, the bone specimens were calcined to obtain the ash weight.Results: QCT analysis (SEQCT, SIM60KeV-QCT) underestimated BMC value compared to DXA. For femoral necks, all QCT analyses provided an unbiased estimate of ash weight but underestimated ash density regardless of the kernel used. For femoral diaphysis, SEQCT BK, SIM60KeV-QCT BK, and SK underestimated ash weight but not ash density.Conclusion: BMC and vBMD quantifications with the SIM60KeV-QCT gave similar results as the SEQCT. Further studies are needed to optimize the use of SIM60KeV-QCT in clinical situations. SK should be used given the effect of kernels on QCT assessment.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-139725" status="OLD">
          <idno type="IdRef">182033775</idno>
          <idno type="ISNI">0000000404503721</idno>
          <idno type="RNSR">201119460J</idno>
          <idno type="ROR">https://ror.org/040zr6b15</idno>
          <orgName>Physiopathologie, diagnostic et traitements des maladies osseuses /  Pathophysiology, Diagnosis &amp; Treatments of Bone Diseases</orgName>
          <orgName type="acronym">LYOS</orgName>
          <date type="end">2020-12-31</date>
          <desc>
            <address>
              <addrLine>UFR de Médecine Lyon-Est -  11 Rue Guillaume Paradin, 69008 Lyon</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.lyos.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-194495" type="direct"/>
            <relation active="#struct-301088" type="indirect"/>
            <relation name="U1033" active="#struct-303623" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300094" status="VALID">
          <idno type="ROR">https://ror.org/02qt1p572</idno>
          <orgName>Hôpital Edouard Herriot [CHU - HCL]</orgName>
          <desc>
            <address>
              <addrLine>5 Place d'Arsonval69003 Lyon</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-lyon.fr/fr/hopital-edouard-herriot</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300074" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-581164" status="VALID">
          <idno type="IdRef">15072411X</idno>
          <idno type="ISNI">0000000406234692</idno>
          <idno type="RNSR">200717404S</idno>
          <orgName>Laboratoire de Biomécanique et Mécanique des Chocs</orgName>
          <orgName type="acronym">LBMC UMR T9406</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>25, avenue François Mitterrand, Cité des mobilités F-69675 Bron Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.lbmc.ifsttar.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-194495" type="direct"/>
            <relation active="#struct-301088" type="indirect"/>
            <relation name="UMR_T9406" active="#struct-580722" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-353860" status="VALID">
          <idno type="ROR">https://ror.org/023xgd207</idno>
          <orgName>Centre Hospitalier Lyon Sud [CHU - HCL]</orgName>
          <orgName type="acronym">CHLS</orgName>
          <desc>
            <address>
              <addrLine>165 Chemin du Grand Revoyet69495 Pierre-Bénite</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-lyon.fr/fr/centre-hospitalier-lyon-sud</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300074" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-194495" status="VALID">
          <idno type="IdRef">026402823</idno>
          <idno type="ISNI">0000000121686185</idno>
          <idno type="ROR">https://ror.org/029brtt94</idno>
          <orgName>Université Claude Bernard Lyon 1</orgName>
          <orgName type="acronym">UCBL</orgName>
          <desc>
            <address>
              <addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-lyon1.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-301088" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-301088" status="VALID">
          <idno type="ROR">https://ror.org/01rk35k63</idno>
          <orgName>Université de Lyon</orgName>
          <desc>
            <address>
              <addrLine>92 rue Pasteur - CS 30122, 69361 Lyon Cedex 07</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.universite-lyon.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-300074" status="VALID">
          <idno type="IdRef">026534657</idno>
          <idno type="ROR">https://ror.org/01502ca60</idno>
          <orgName>Hospices Civils de Lyon</orgName>
          <orgName type="acronym">HCL</orgName>
          <desc>
            <address>
              <addrLine>3 Quai des Célestins69002 Lyon</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-lyon.fr/fr/hospices-civils-de-lyon-hcl</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-580722" status="VALID">
          <idno type="ROR">https://ror.org/03x42jk29</idno>
          <orgName>Université Gustave Eiffel</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>Cité Descartes, 5 Boulevard Descartes • Champs-sur-Marne, 77454 Marne-la-Vallée Cedex 2</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-gustave-eiffel.fr/</ref>
          </desc>
        </org>
      </listOrg>
      <listOrg type="projects">
        <org type="anrProject" xml:id="projanr-41424" status="VALID">
          <idno type="anr">ANR-14-CE35-0030</idno>
          <idno type="program">Appel à projets générique</idno>
          <orgName>TaCo-Sound</orgName>
          <desc>Targeting cortical bone quality by ultrasound biomarkers - relations to porosity, stiffness and strength</desc>
          <date type="start">2014</date>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>