Biodegradable magnesium barrier membrane used for guided bone regeneration in dental surgery - Archive ouverte HAL
Article Dans Une Revue Bioactive Materials Année : 2021

Biodegradable magnesium barrier membrane used for guided bone regeneration in dental surgery

Patrick Rider
  • Fonction : Auteur
Željka Kačarević
  • Fonction : Auteur
Akiva Elad
  • Fonction : Auteur
Drazen Tadic
  • Fonction : Auteur
Daniel Rothamel
  • Fonction : Auteur
Gerrit Sauer
  • Fonction : Auteur
Fabien Bornert
  • Fonction : Auteur
  • PersonId : 1098578
Peter Windisch
  • Fonction : Auteur
Dávid Hangyási
  • Fonction : Auteur
Balint Molnar
  • Fonction : Auteur
Emely Bortel
  • Fonction : Auteur
Bernhard Hesse
  • Fonction : Auteur
Frank Witte
  • Fonction : Auteur

Résumé

Barrier membranes are commonly used as part of the dental surgical technique guided bone regeneration (GBR) and are often made of resorbable collagen or non-resorbable materials such as PTFE. While collagen membranes do not provide sufficient mechanical protection of the covered bone defect, titanium reinforced membranes and non-resorbable membranes need to be removed in a second surgery. Thus, biodegradable GBR membranes made of pure magnesium might be an alternative. In this study a biodegradable pure magnesium (99.95%) membrane has been proven to have all of the necessary requirements for an optimal regenerative outcome from both a mechanical and biological perspective. After implantation, the magnesium membrane separates the regenerating bone from the overlying, faster proliferating soft tissue. During the initial healing period, the membrane maintained a barrier function and space provision, whilst retaining the positioning of the bone graft material within the defect space. As the magnesium metal corroded, it formed a salty corrosion layer and local gas cavities, both of which extended the functional lifespan of the membrane barrier capabilities. During the resorption of the magnesium metal and magnesium salts, it was observed that the membrane became surrounded and then replaced by new bone. After the membrane had completely resorbed, only healthy tissue remained. The in vivo performance study demonstrated that the magnesium membrane has a comparable healing response and tissue regeneration to that of a resorbable collagen membrane. Overall, the magnesium membrane demonstrated all of the ideal qualities for a barrier membrane used in GBR treatment.

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Biotechnologies
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Dates et versions

hal-03462619 , version 1 (01-12-2021)

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Patrick Rider, Željka Kačarević, Akiva Elad, Drazen Tadic, Daniel Rothamel, et al.. Biodegradable magnesium barrier membrane used for guided bone regeneration in dental surgery. Bioactive Materials, 2021, ⟨10.1016/j.bioactmat.2021.11.018⟩. ⟨hal-03462619⟩

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