KAT2-mediated PLK4 acetylation contributes to genomic stability by preserving centrosome number - Archive ouverte HAL Access content directly
Journal Articles Molecular & Cellular Oncology Year : 2016

KAT2-mediated PLK4 acetylation contributes to genomic stability by preserving centrosome number

Abstract

We have recently identified the first human lysine (K) acetyltransferase 2A and 2B (called KAT2A/2B; known also as GCN5/PCAF, respectively)-dependent acetylome and revealed a mechanism by which KAT2A/2B-mediated acetylation of serine/threonine polo-like kinase 4 (PLK4) maintains correct centrosome number in human cells, therefore contributing to the maintenance of genome stability
Fichier principal
Vignette du fichier
kmco-04-02-1270391.pdf (499.24 Ko) Télécharger le fichier
Origin Publisher files allowed on an open archive

Dates and versions

hal-03457183 , version 1 (04-01-2024)

Identifiers

Cite

Marjorie Fournier, László Tora. KAT2-mediated PLK4 acetylation contributes to genomic stability by preserving centrosome number. Molecular & Cellular Oncology, 2016, 4 (2), pp.e1270391. ⟨10.1080/23723556.2016.1270391⟩. ⟨hal-03457183⟩
41 View
7 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More