Scalable Batch Fabrication of Ultrathin Flexible Neural Probes using Bioresorbable Silk Layer - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Microsystems & Nanoengineering Année : 2022

Scalable Batch Fabrication of Ultrathin Flexible Neural Probes using Bioresorbable Silk Layer

Résumé

Flexible deep brain probes have been the focus of many research works and aims at achieving better compliance with the surrounding brain tissue while maintaining minimal rejection. Strategies have been explored to find the best way to implant a flexible probe in the brain, while maintaining its flexibility once positioned in the cortex. Here, we present a novel and versatile scalable batch fabrication approach to deliver ultra-thin and flexible penetrating neural probe consisting of a silk-parylene bilayer. The biodegradable silk layer provides a temporary and programmable stiffener to ensure ease of insertion of the ultrathin parylene-based flexible devices. The innovative and yet robust batch fabrication technology allows complete design freedom of the neural probe in terms of materials, size, shape and thickness. These results provide a novel technological solution for implanting ultra-flexible and ultrathin devices, which possesses great potential for brain research.
Fichier principal
Vignette du fichier
s41378-022-00353-7(11).pdf (2.17 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-03456630 , version 1 (28-11-2022)

Identifiants

Citer

Clement Cointe, Adrian Laborde, Lionel Nowak, Dina N Arvanitis, David Bourrier, et al.. Scalable Batch Fabrication of Ultrathin Flexible Neural Probes using Bioresorbable Silk Layer. Microsystems & Nanoengineering, 2022, 8, pp.21. ⟨10.1038/s41378-022-00353-7⟩. ⟨hal-03456630⟩
281 Consultations
154 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More