Synergistic Copper/Enamine Catalysis for the Regio-,Stereo-and Enantioselective Intermolecular α-Addition of Aldehydes to Allenamides
Résumé
We herein describe an intermolecular enantioselective α-addition of aldehydes to allenamides, using a dual copper / enamine catalytic system. Highly enantioselective addition of aldehydes were obtained thanks to secondary amine catalysts. The process was found to be highly regio-, stereo-and enantio-selective under mild conditions.
Domaines
Chimie organique| Origine | Fichiers produits par l'(les) auteur(s) |
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