Synergistic Copper/Enamine Catalysis for the Regio-,Stereo-and Enantioselective Intermolecular α-Addition of Aldehydes to Allenamides - Archive ouverte HAL
Article Dans Une Revue Organic Letters Année : 2021

Synergistic Copper/Enamine Catalysis for the Regio-,Stereo-and Enantioselective Intermolecular α-Addition of Aldehydes to Allenamides

Résumé

We herein describe an intermolecular enantioselective α-addition of aldehydes to allenamides, using a dual copper / enamine catalytic system. Highly enantioselective addition of aldehydes were obtained thanks to secondary amine catalysts. The process was found to be highly regio-, stereo-and enantio-selective under mild conditions.

Domaines

Chimie organique
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Dates et versions

hal-03455775 , version 1 (29-11-2021)

Identifiants

Citer

Rémi Blieck, Sébastien Lemouzy, Arie van Der Lee, Marc Taillefer, Florian Monnier. Synergistic Copper/Enamine Catalysis for the Regio-,Stereo-and Enantioselective Intermolecular α-Addition of Aldehydes to Allenamides. Organic Letters, 2021, ⟨10.1021/acs.orglett.1c03477⟩. ⟨hal-03455775⟩
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