Iatrogenic transmission of Alzheimer's disease: Evidence based on experimental inoculation of Alzheimer's brains into a primate - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Alzheimer's & Dementia : the Journal of the Alzheimer's Association Année : 2020

Iatrogenic transmission of Alzheimer's disease: Evidence based on experimental inoculation of Alzheimer's brains into a primate

Suzanne Lam
  • Fonction : Auteur
Charlotte Gary
  • Fonction : Auteur
Anne‐sophie Herard
  • Fonction : Auteur
James Koch
  • Fonction : Auteur
Fanny Petit
  • Fonction : Auteur
Pauline Gipchtein
  • Fonction : Auteur
Stephen Sawiak
  • Fonction : Auteur
Raphaelle Caillierez
  • Fonction : Auteur
Sabiha Eddarkaoui
  • Fonction : Auteur
Morvane Colin
Fabienne Aujard
Jean‐philippe Deslys
  • Fonction : Auteur
Charles Duyckaerts
  • Fonction : Auteur
Emmanuel Brouillet
Emmanuel Comoy
  • Fonction : Auteur
Fabien Pifferi
  • Fonction : Auteur
Jean‐luc Picq

Résumé

Background: Epidemiologic data suggest that, in humans, iatrogenic administration of compounds (cadaver-sourced human growth hormone, dura mater graft) or cerebral surgeries with tools contaminated with Aβ and tau induce aggregated Aβ and possibly tau lesions. Aβ and tau lesions could thus be iatrogenically transmitted to humans. Several studies in mice have shown that experimental inoculation of amyloid and/or taupositive brain samples into transgenic (tg) mouse models overexpressing Aβ or tau promotes either Aβ or tau aggregation in the brain of the recipient animal. Unlike rodents, primates naturally express Aβ or tau under normal conditions and they have a biochemical and physical cerebral environment that is closer to that of humans than that of mice. The aim of this work was to evaluate the impact of human brain samples inoculations in the mouse lemur primates.

Domaines

Neurobiologie
Fichier principal
Vignette du fichier
Dhenain-AlzDementia-2020.pdf (70.42 Ko) Télécharger le fichier
Origine Accord explicite pour ce dépôt

Dates et versions

hal-03453400 , version 1 (02-11-2023)

Identifiants

Citer

Marc Dhenain, Suzanne Lam, Charlotte Gary, Anne‐sophie Herard, James Koch, et al.. Iatrogenic transmission of Alzheimer's disease: Evidence based on experimental inoculation of Alzheimer's brains into a primate. Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2020, 16 (S2), ⟨10.1002/alz.042957⟩. ⟨hal-03453400⟩
10 Consultations
9 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More