Article Dans Une Revue Bioconjugate Chemistry Année : 2021

Flavin-Conjugated Nanobombs: Key Structural Requirements Governing Their Self-Assemblies’ Morphologies

Résumé

In contrast to artificial molecules, natural photosensitizers have the benefit of excellent toxicity profiles and of life-compatible activating energy ranges. Flavins are such photosensitizers that were selected by nature in a plethora of light-triggered biochemical reactions. Flavin-rich nanoparticles could thus emerge as promising tools in photodynamic therapies and in active-targeting drug delivery. Selfassembled flavin-conjugated phospholipids improve the pharmacokinetics of natural flavins and, in the case of controlled morphologies, reduce photobleaching phenomena. The current article presents a proof of concept for the design of riboflavin-rich nanoparticles of tunable morphology from multilamellar patches to vesicular self-assemblies. Coarse-grained simulations of the self-assembling process revealed the key interactions governing the obtained nanomaterials and successfully guided the synthesis of new flavin-conjugates of predictable self-assembly. The obtained flavin-based liposomes had a 65 nm hydrodynamic diameter, were stable, and showed potential photosensitizer activity.

Domaines

Fichier principal
Vignette du fichier
acs.bioconjchem.1c00028.pdf (3.93 Mo) Télécharger le fichier
Origine Fichiers éditeurs autorisés sur une archive ouverte
Licence

Dates et versions

hal-03448525 , version 1 (25-11-2021)

Licence

Identifiants

Citer

Jonathan Ribes, Nataliia Beztsinna, Remy Bailly, Sabine Castano, Estelle Rascol, et al.. Flavin-Conjugated Nanobombs: Key Structural Requirements Governing Their Self-Assemblies’ Morphologies. Bioconjugate Chemistry, 2021, 32, pp.553 - 562. ⟨10.1021/acs.bioconjchem.1c00028⟩. ⟨hal-03448525⟩
85 Consultations
287 Téléchargements

Altmetric

Partager

  • More