Comprehensive integrative profiling of upper tract urothelial carcinomas - Archive ouverte HAL Access content directly
Journal Articles Genome Biology Year : 2021

Comprehensive integrative profiling of upper tract urothelial carcinomas


Abstract Background Crosstalk between genetic, epigenetic, and immune alterations in upper tract urothelial carcinomas and their role in shaping muscle invasiveness and patient outcome are poorly understood. Results We perform an integrative genome- and methylome-wide profiling of diverse non-muscle-invasive and muscle-invasive upper tract urothelial carcinomas. In addition to mutations of FGFR3 and KDM6A , we identify ZFP36L1 as a novel, significantly mutated tumor suppressor gene. Overall, mutations of ZFP36 family genes ( ZFP36 , ZFP36L1 , and ZFP36L2 ) are identified in 26.7% of cases, which display a high mutational load. Unsupervised DNA methylation subtype classification identifies two epi-clusters associated with distinct muscle-invasive status and patient outcome, namely, EpiC-low and EpiC-high. While the former is hypomethylated, immune-depleted, and enriched for FGFR3 -mutated, the latter is hypermethylated, immune-infiltrated, and tightly associated with somatic mutations of SWI/SNF genes. Conclusions Our study delineates for the first time the key role for convergence between genetic and epigenetic alterations in shaping clinicopathological and immune upper tract urothelial carcinoma features.
Fichier principal
Vignette du fichier
PDF Datastream.pdf (2.61 Mo) Télécharger le fichier
Origin Publication funded by an institution

Dates and versions

hal-03445544 , version 1 (18-11-2022)



Xiaoping Su, Xiaofan Lu, Sehrish Khan Bazai, Eva Compérat, Roger Mouawad, et al.. Comprehensive integrative profiling of upper tract urothelial carcinomas. Genome Biology, 2021, 22 (1), ⟨10.1186/s13059-020-02230-w⟩. ⟨hal-03445544⟩
31 View
15 Download



Gmail Mastodon Facebook X LinkedIn More