Thermodynamical framework for modeling chemo-mechanical coupling in muscle contraction ? Formulation and preliminary results - Archive ouverte HAL Accéder directement au contenu
Communication Dans Un Congrès Année : 2015

Thermodynamical framework for modeling chemo-mechanical coupling in muscle contraction ? Formulation and preliminary results

Matthieu Caruel
  • Fonction : Auteur
Philippe Moireau
Dominique Chapelle
  • Fonction : Auteur

Résumé

We propose a multiscale model of cardiac contraction in which the molecular motors at the origin of the contractile process are considered as multistable mechanical entities endowed with internal degrees of freedom of both mechanical and chemical nature. This model provides a thermodynamical basis for modeling the complex interplay of chemical and mechanical phenomena at the sub-cellular level. Important motivations for this work include the ability to represent the experimentally observed physiological characteristics of the contractile apparatus such as (i) the passive quick force recovery mechanism, (ii) the relation between the contraction velocity and the applied force and (iii) the so called Lymn-Taylor cycle describing the metabolism.
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hal-03444980 , version 1 (23-11-2021)

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  • HAL Id : hal-03444980 , version 1

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Matthieu Caruel, Philippe Moireau, Dominique Chapelle. Thermodynamical framework for modeling chemo-mechanical coupling in muscle contraction ? Formulation and preliminary results. CFM 2015 - 22ème Congrès Français de Mécanique, Aug 2015, Lyon, France. ⟨hal-03444980⟩

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