Regulation of glycolysis and cancer cell proliferation by PKM2 citrullination - Archive ouverte HAL Access content directly
Journal Articles Molecular & Cellular Oncology Year : 2021

Regulation of glycolysis and cancer cell proliferation by PKM2 citrullination

Abstract

Conversion of peptidyl-arginine to peptidyl citrulline, known as citrullination, is a posttranslational protein modification catalysed by the PADI (Protein Arginine Deiminase) family of enzymes. PADI1 and PADI3 catalyse citrullination of arginine 106 in the glycolytic enzyme pyruvate kinase M2 modulating its allosteric regulation, glycolysis and cancer cell proliferation.
Fichier principal
Vignette du fichier
2021-KMCO-0041_R1 (1).pdf (1.03 Mo) Télécharger le fichier

Dates and versions

hal-03442215 , version 1 (23-11-2021)

Identifiers

Cite

Sébastien Coassolo, Irwin Davidson. Regulation of glycolysis and cancer cell proliferation by PKM2 citrullination. Molecular & Cellular Oncology, 2021, 8 (4), ⟨10.1080/23723556.2021.1927446⟩. ⟨hal-03442215⟩
14 View
39 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More