In this paper, we investigate the behavior of biological tissues (skin) coupled to a substrate (sensor) based on a numerical model taking into account the relationship between strain/stress components at the interface. Based on this study, we understand and quantify the most appropriate biomechanical factors in order to optimize sensor/biological tissue interface conditions. A micromechanical description based on a mathematical formulation has been developed to evaluate the biomechanical behavior provided by a 2D viscoelastic model of Kelvin–Voigt. The results show a spatio-temporal law of tissue motion highlighting the need for an optimized interface for reliable data transmission in the case of connected device in a dynamic movement or in the manufacturing of intelligent and reactive prosthesis device.