Spider orb webs are versatile multifunctional structures with optimized mechanical properties for prey capture, but also for transmitting vibrations. The versatility of such a system mainly derives from its variable geometry, which can be effectively used to design phononic crystals, thus inhibiting wave propagation in wide frequency ranges. In this work, the design of spider web-inspired singlephase phononic crystals through selective variation of thread radii and the addition of point masses is proposed, determined through the use of optimization techniques. The obtained results show that spider web geometry displays a rich vibration spectrum, which by varying its the geometric characteristics and adding localized masses can be tailored to manipulate wave modes, and the resulting two-dimensional phononic crystals present wide complete band gaps generated by Bragg scattering and local resonances.