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Article Dans Une Revue Biomacromolecules Année : 2016

Immunomodulation with Self-Crosslinked Polyelectrolyte Multilayer-Based Coatings

Résumé

This study aims to design an optimal polyelectrolyte multilayer film of poly-l-lysine (PLL) and hyaluronic acid (HA) as an anti-inflammatory cytokine release system in order to decrease the implant failure due to any immune reactions. The chemical modification of the HA with aldehyde moieties allows self-cross-linking of the film and an improvement in the mechanical properties of the film. The cross-linking of the film and the release of immunomodulatory cytokine (IL-4) stimulate the differentiation of primary human monocytes seeded on the films into pro-healing macrophages phenotype. This induces the production of anti-inflammatory cytokines (IL1-RA and CCL18) and the decrease of pro-inflammatory cytokines secreted (IL-12, TNF-α, and IL-1β). Moreover, we demonstrate that cross-linking PLL/HA film using HA-aldehyde is already effective by itself to limit inflammatory processes. Finally, this functionalized self-cross-linked PLL/HA-aldehyde films constitutes an innovative and efficient candidate for immunomodulation of any kind of implants of various architecture and properties.

Dates et versions

hal-03437503 , version 1 (19-11-2021)

Identifiants

Citer

Helena Knopf-Marques, Sonali Singh, Su Su Htwe, Lucie Wolfova, Radovan Buffa, et al.. Immunomodulation with Self-Crosslinked Polyelectrolyte Multilayer-Based Coatings. Biomacromolecules, 2016, 17 (6), pp.2189-2198. ⟨10.1021/acs.biomac.6b00429⟩. ⟨hal-03437503⟩
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