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Article Dans Une Revue Current Opinion in Chemical Biology Année : 2021

Metal-based environment-sensitive MRI contrast agents

Celia ́ Bonnet
Éva Tóth

Résumé

Interactions of paramagnetic metal complexes with their biological environment can modulate their magnetic resonance imaging (MRI) contrast-enhancing properties in different ways, and this has been widely exploited to create responsive probes that can provide biochemical information. We survey progress in two rapidly growing areas: the MRI detection of biologically important metal ions, such as calcium, zinc, and copper, and the use of transition metal complexes as smart MRI agents. In both fields, new imaging technologies, which take advantage of other nuclei (19F) and/or paramagnetic contact shift effects, emerge beyond classical, relaxation-based applications. Most importantly, in vivo imaging is gaining ground, and the promise of molecular MRI is becoming reality, at least for preclinical research.
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hal-03437175 , version 1 (19-11-2021)

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Celia ́ Bonnet, Éva Tóth. Metal-based environment-sensitive MRI contrast agents. Current Opinion in Chemical Biology, 2021, 61, pp.154-169. ⟨10.1016/j.cbpa.2021.01.013⟩. ⟨hal-03437175⟩
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