Within-host genetic micro-diversity of Mycobacterium tuberculosis and the link with tuberculosis disease features - Archive ouverte HAL Access content directly
Preprints, Working Papers, ... Year : 2021

Within-host genetic micro-diversity of Mycobacterium tuberculosis and the link with tuberculosis disease features

Abstract

Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb) complex, is still the number one deadly contagious disease. Mtb infection results in a wide spectrum of clinical presentations and severity symptoms, but without proven Mtb genetic determinants. Thanks to a collection of 355 clinical isolates with associated patient’s clinical data, we showed that Mtb micro-diversity within patient isolates is strongly correlated with TB-associated severity scores. Interestingly, this diversity is driven by a selection pressure to adapt to different lifestyles related to the infection site. Taken together, these results provide a new insight to better understand TB pathophysiology. Furthermore, Mtb micro-diversity could be envisioned as a new prognostic tool to improve the management of TB patients.

Domains

Bacteriology

Dates and versions

hal-03433572 , version 1 (17-11-2021)

Identifiers

Cite

Charlotte Genestet, Elisabeth Hodille, François Massol, Guislaine Refrégier, Alexia Barbry, et al.. Within-host genetic micro-diversity of Mycobacterium tuberculosis and the link with tuberculosis disease features. 2021. ⟨hal-03433572⟩

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