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Journal Articles Mammalian Genome Year : 2022

INFRAFRONTIER quality principles in systemic phenotyping

Hilke Ehlich
Heather Cater
Anne-Marie Mura
Michael Raess
Mohammed Selloum
Reetta Vuolteenaho
Steve Brown
Reetta Hinttala
Bernard Malissen
Sara Wells
Ana Zarubica
Tania Sorg


Improving reproducibility and replicability in preclinical research is a widely discussed and pertinent topic, especially regarding ethical responsibility in animal research. INFRAFRONTIER, the European Research Infrastructure for the generation, phenotyping, archiving, and distribution of model mammalian genomes, is addressing this issue by developing internal quality principles for its different service areas, that provides a quality framework for its operational activities. This article introduces the INFRAFRONTIER Quality Principles in Systemic Phenotyping of genetically altered mouse models. A total of 11 key principles are included, ranging from general requirements for compliance with guidelines on animal testing, to the need for well-trained personnel and more specific standards such as the exchange of reference lines. Recently established requirements such as the provision of FAIR (Findable, Accessible, Interoperable, Reusable) data are also addressed. For each quality principle, we have outlined the specific context, requirements, further recommendations, and key references.
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Origin : Publication funded by an institution

Dates and versions

hal-03433476 , version 1 (14-12-2022)





Hilke Ehlich, Heather Cater, Ann Flenniken, Isabelle Goncalves da Cruz, Anne-Marie Mura, et al.. INFRAFRONTIER quality principles in systemic phenotyping. Mammalian Genome, 2022, 33 (1), pp.120-122. ⟨10.1007/s00335-021-09892-2⟩. ⟨hal-03433476⟩
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