African Gene Flow Reduces Beta-Ionone Anosmia/Hyposmia Prevalence in Admixed Malagasy Populations - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Brain Sciences Année : 2021

African Gene Flow Reduces Beta-Ionone Anosmia/Hyposmia Prevalence in Admixed Malagasy Populations

Thierry Talou
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Monique Courtade-Saidi
Chantal Radimilahy
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Thierry Letellier
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Denis Pierron

Résumé

While recent advances in genetics make it possible to follow the genetic exchanges between populations and their phenotypic consequences, the impact of the genetic exchanges on the sensory perception of populations has yet to be explored. From this perspective, the present study investi- gated the consequences of African gene flow on odor perception in a Malagasy population with a predominantly East Asian genetic background. To this end, we combined psychophysical tests with genotype data of 235 individuals who were asked to smell the odorant molecule beta-ionone (βI). Results showed that in this population the ancestry of the OR5A1 gene significantly influences the ability to detect βI. At the individual level, African ancestry significantly protects against specific anosmia/hyposmia due to the higher frequency of the functional gene (OR ratios = 14, CI: 1.8–110, p-value = 0.012). At the population level, African introgression decreased the prevalence of specific anosmia/hyposmia to this odorous compound. Taken together, these findings validate the conjecture that in addition to cultural exchanges, genetic transfer may also influence the sensory perception of the population in contact.
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hal-03432438 , version 1 (17-11-2021)

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Harilanto Razafindrazaka, Veronica Pereda-Loth, Camille Ferdenzi, Margit Heiske, Omar Alva, et al.. African Gene Flow Reduces Beta-Ionone Anosmia/Hyposmia Prevalence in Admixed Malagasy Populations. Brain Sciences, 2021, 11 (11), pp.1405. ⟨10.3390/brainsci11111405⟩. ⟨hal-03432438⟩
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