<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-03429543</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-17T08:08:23+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Zebrafish model to assess ecotoxicological impacts of cosmetic products preservatives: case of parabens and their substitutes</title>
            <author role="aut">
              <persName>
                <forename type="first">Christophe</forename>
                <surname>Morin</surname>
              </persName>
              <email type="md5">017bbf6c148fa0f1c76aedbb5768a414</email>
              <email type="domain">u-pec.fr</email>
              <idno type="idhal" notation="string">christophe-morin23</idno>
              <idno type="idhal" notation="numeric">15130</idno>
              <idno type="halauthorid" notation="string">26148-15130</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-2490-7585</idno>
              <idno type="IDREF">https://www.idref.fr/175056870</idno>
              <affiliation ref="#struct-578082"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Adèle</forename>
                <surname>Bressy</surname>
              </persName>
              <email type="md5">e2041a3662e7a53987c708c82d4de9a8</email>
              <email type="domain">enpc.fr</email>
              <idno type="idhal" notation="string">adele-bressy</idno>
              <idno type="idhal" notation="numeric">4080</idno>
              <idno type="halauthorid" notation="string">21583-4080</idno>
              <idno type="IDREF">https://www.idref.fr/150548850</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-9951-2572</idno>
              <affiliation ref="#struct-578082"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Melissa</forename>
                <surname>Saichi</surname>
              </persName>
              <idno type="idhal" notation="numeric">1613125</idno>
              <idno type="halauthorid" notation="string">2337421-1613125</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-6461-1482</idno>
              <affiliation ref="#struct-578082"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Clement</forename>
                <surname>Leroyer</surname>
              </persName>
              <idno type="halauthorid">1307576-0</idno>
              <affiliation ref="#struct-578082"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Yaël</forename>
                <surname>Guttmann</surname>
              </persName>
              <idno type="halauthorid">1895478-0</idno>
              <affiliation ref="#struct-578082"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">R.</forename>
                <surname>Moilleron</surname>
              </persName>
              <email type="md5">f031a239f82176fb71644cd6a88517c6</email>
              <email type="domain">u-pec.fr</email>
              <idno type="idhal" notation="string">regis-moilleron</idno>
              <idno type="idhal" notation="numeric">3971</idno>
              <idno type="halauthorid" notation="string">14508-3971</idno>
              <idno type="IDREF">https://www.idref.fr/083826963</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-8876-7123</idno>
              <affiliation ref="#struct-578082"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Laure</forename>
                <surname>Garrigue-Antar</surname>
              </persName>
              <email type="md5">eac538217fe04d9ee5aa4d40df8b3beb</email>
              <email type="domain">u-pec.fr</email>
              <idno type="idhal" notation="string">laure-garrigue-antar</idno>
              <idno type="idhal" notation="numeric">15824</idno>
              <idno type="halauthorid" notation="string">7060-15824</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-6331-8882</idno>
              <idno type="IDREF">https://www.idref.fr/182858340</idno>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Adèle</forename>
                <surname>Bressy</surname>
              </persName>
              <email type="md5">e2041a3662e7a53987c708c82d4de9a8</email>
              <email type="domain">enpc.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2021-11-15 17:16:34</date>
              <date type="whenModified">2026-02-07 05:22:07</date>
              <date type="whenReleased">2021-11-29 15:29:29</date>
              <date type="whenProduced">2019-06</date>
              <ref type="annex" n="1" target="https://hal.science/hal-03429543v1/file/ICCE-2019_Morin.pdf" id="file-3429543-3006674">
                <date notBefore="2021-11-15"/>
              </ref>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="170069">
                <persName>
                  <forename>Adèle</forename>
                  <surname>Bressy</surname>
                </persName>
                <email type="md5">e2041a3662e7a53987c708c82d4de9a8</email>
                <email type="domain">enpc.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-03429543</idno>
            <idno type="halUri">https://hal.science/hal-03429543</idno>
            <idno type="halBibtex">morin:hal-03429543</idno>
            <idno type="halRefHtml">&lt;i&gt;17th International Conference on Chemistry and the Environment&lt;/i&gt;, Jun 2019, Thessaloniki, Greece</idno>
            <idno type="halRef">17th International Conference on Chemistry and the Environment, Jun 2019, Thessaloniki, Greece</idno>
            <availability status="restricted">
              <licence target="https://about.hal.science/hal-authorisation-v1/">HAL Authorization<ref corresp="#file-3429543-3006674"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="SDE">Sciences De l'Environnement</idno>
            <idno type="stamp" n="ENPC" corresp="PARISTECH">École nationale des ponts et chaussées </idno>
            <idno type="stamp" n="PARISTECH">ParisTech</idno>
            <idno type="stamp" n="ENPC-LEESU" corresp="ENPC">Laboratoire Eau Environnement et Systèmes Urbains</idno>
            <idno type="stamp" n="GIP-BE">GIP Bretagne Environnement</idno>
            <idno type="stamp" n="UPEC" corresp="CV_UPEC">Université Paris-Est Créteil Val-de-Marne</idno>
            <idno type="stamp" n="ORGANICEPRINTS">Organic Eprints Collection</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="invited" n="0">No</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
            <note type="proceedings" n="0">No</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Zebrafish model to assess ecotoxicological impacts of cosmetic products preservatives: case of parabens and their substitutes</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Christophe</forename>
                    <surname>Morin</surname>
                  </persName>
                  <email type="md5">017bbf6c148fa0f1c76aedbb5768a414</email>
                  <email type="domain">u-pec.fr</email>
                  <idno type="idhal" notation="string">christophe-morin23</idno>
                  <idno type="idhal" notation="numeric">15130</idno>
                  <idno type="halauthorid" notation="string">26148-15130</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-2490-7585</idno>
                  <idno type="IDREF">https://www.idref.fr/175056870</idno>
                  <affiliation ref="#struct-578082"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Adèle</forename>
                    <surname>Bressy</surname>
                  </persName>
                  <email type="md5">e2041a3662e7a53987c708c82d4de9a8</email>
                  <email type="domain">enpc.fr</email>
                  <idno type="idhal" notation="string">adele-bressy</idno>
                  <idno type="idhal" notation="numeric">4080</idno>
                  <idno type="halauthorid" notation="string">21583-4080</idno>
                  <idno type="IDREF">https://www.idref.fr/150548850</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-9951-2572</idno>
                  <affiliation ref="#struct-578082"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Melissa</forename>
                    <surname>Saichi</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1613125</idno>
                  <idno type="halauthorid" notation="string">2337421-1613125</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-6461-1482</idno>
                  <affiliation ref="#struct-578082"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Clement</forename>
                    <surname>Leroyer</surname>
                  </persName>
                  <idno type="halauthorid">1307576-0</idno>
                  <affiliation ref="#struct-578082"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Yaël</forename>
                    <surname>Guttmann</surname>
                  </persName>
                  <idno type="halauthorid">1895478-0</idno>
                  <affiliation ref="#struct-578082"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">R.</forename>
                    <surname>Moilleron</surname>
                  </persName>
                  <email type="md5">f031a239f82176fb71644cd6a88517c6</email>
                  <email type="domain">u-pec.fr</email>
                  <idno type="idhal" notation="string">regis-moilleron</idno>
                  <idno type="idhal" notation="numeric">3971</idno>
                  <idno type="halauthorid" notation="string">14508-3971</idno>
                  <idno type="IDREF">https://www.idref.fr/083826963</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-8876-7123</idno>
                  <affiliation ref="#struct-578082"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Laure</forename>
                    <surname>Garrigue-Antar</surname>
                  </persName>
                  <email type="md5">eac538217fe04d9ee5aa4d40df8b3beb</email>
                  <email type="domain">u-pec.fr</email>
                  <idno type="idhal" notation="string">laure-garrigue-antar</idno>
                  <idno type="idhal" notation="numeric">15824</idno>
                  <idno type="halauthorid" notation="string">7060-15824</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-6331-8882</idno>
                  <idno type="IDREF">https://www.idref.fr/182858340</idno>
                </author>
              </analytic>
              <monogr>
                <meeting>
                  <title>17th International Conference on Chemistry and the Environment</title>
                  <date type="start">2019-06</date>
                  <settlement>Thessaloniki</settlement>
                  <country key="GR">Greece</country>
                </meeting>
                <imprint/>
              </monogr>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">zebrafish</term>
                <term xml:lang="en">preservatives</term>
                <term xml:lang="en">personal care products</term>
                <term xml:lang="en">ecotoxicological impacts</term>
                <term xml:lang="en">cocktail effect</term>
              </keywords>
              <classCode scheme="halDomain" n="sde">Environmental Sciences</classCode>
              <classCode scheme="halTypology" n="POSTER">Poster communications</classCode>
              <classCode scheme="halOldTypology" n="POSTER">Poster communications</classCode>
              <classCode scheme="halTreeTypology" n="POSTER">Poster communications</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Parabens were widely used as preservatives and antimicrobial agents in most personal care products (PCPs). Because of their ubiquitous presence in surface waters worldwide, and their potentially negative effect as endocrine disruptors on aquatic ecosystems, these molecules raise increasing concern. Following Darbre et al publication in 2004, which established a potential link between parabens and breast cancer, consumers' increasing awareness prompted cosmetic industry to seek alternatives to parabens by developing "paraben free" or "organic" products in the formulations, processes and packaging. Key unresolved issues include the identification of the products which should be substituted, and their replacement by other potentially harmful substances. The objectives of our studies were (i) to determine which chemicals replace parabens; and (ii) to evaluate the toxicity of these molecules on the development and the behavior of zebrafish (Danio rerio) larvae. The use of zebrafish larvae is a promising and robust tool to assess toxicological impacts of parabens and their substitutes in the environment. In particular, this model could enable to generate valuable data on cocktail effects, which remain to date poorly documented in environmental conditions.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-578082" status="OLD">
          <idno type="IdRef">149211538</idno>
          <idno type="RNSR">200920634U</idno>
          <idno type="ROR">https://ror.org/02nqy7n35</idno>
          <idno type="Wikidata">Q51783936</idno>
          <orgName>Laboratoire Eau Environnement et Systèmes Urbains</orgName>
          <orgName type="acronym">LEESU</orgName>
          <date type="start">2020-01-01</date>
          <date type="end">2024-12-31</date>
          <desc>
            <address>
              <addrLine>6-8 avenue Blaise Pascal, Cité Descartes, Champs sur Marne77 455 Marne-La-Vallée Cedex 2</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.leesu.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-301545" type="direct"/>
            <relation active="#struct-420786" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-301545" status="OLD">
          <idno type="ROR">https://ror.org/02nwvxz07</idno>
          <orgName>École nationale des ponts et chaussées</orgName>
          <orgName type="acronym">ENPC</orgName>
          <date type="start">1747-02-14</date>
          <date type="end">2024-12-31</date>
          <desc>
            <address>
              <addrLine>École nationale des ponts et chaussées, 6-8 avenue Blaise-Pascal, Cité Descartes, Champs-sur-Marne, 77455 Marne-la-Vallée cedex 2</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://ecoledesponts.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-420786" status="VALID">
          <idno type="IdRef">028021037</idno>
          <idno type="ISNI">0000000121497878</idno>
          <idno type="ROR">https://ror.org/05ggc9x40</idno>
          <orgName>Université Paris-Est Créteil Val-de-Marne - Paris 12</orgName>
          <orgName type="acronym">UPEC UP12</orgName>
          <date type="start">1970-01-01</date>
          <desc>
            <address>
              <addrLine>61 avenue du Général de Gaulle - 94010 Créteil cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.u-pec.fr/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>