<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-03424056</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-17T05:07:44+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Ligands and DNA in the allosteric control of retinoid receptors function</title>
            <author role="aut">
              <persName>
                <forename type="first">Pierre</forename>
                <surname>Germain</surname>
              </persName>
              <email type="md5">0488d2a7fab83238a3c11329c7164f17</email>
              <email type="domain">cbs.cnrs.fr</email>
              <idno type="idhal" notation="numeric">1235972</idno>
              <idno type="halauthorid" notation="string">102165-1235972</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-2962-9593</idno>
              <affiliation ref="#struct-59411"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Natacha</forename>
                <surname>Rochel</surname>
              </persName>
              <email type="md5">ab3cf19f82949b7aff218dfc351b11dd</email>
              <email type="domain">igbmc.fr</email>
              <idno type="idhal" notation="string">natacha-rochel</idno>
              <idno type="idhal" notation="numeric">740505</idno>
              <idno type="halauthorid" notation="string">5579-740505</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-3573-5889</idno>
              <idno type="IDREF">https://www.idref.fr/183592468</idno>
              <affiliation ref="#struct-93800"/>
            </author>
            <author role="crp">
              <persName>
                <forename type="first">William</forename>
                <surname>Bourguet</surname>
              </persName>
              <email type="md5">1c3ccb966cad149ed3a0330296a9cbab</email>
              <email type="domain">cbs.cnrs.fr</email>
              <idno type="idhal" notation="string">william-bourguet</idno>
              <idno type="idhal" notation="numeric">758185</idno>
              <idno type="halauthorid" notation="string">213347-758185</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-0643-7719</idno>
              <idno type="IDREF">https://www.idref.fr/084740191</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/I-5569-2013</idno>
              <affiliation ref="#struct-59411"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Natacha</forename>
                <surname>Rochel</surname>
              </persName>
              <email type="md5">ab3cf19f82949b7aff218dfc351b11dd</email>
              <email type="domain">igbmc.fr</email>
            </editor>
            <funder ref="#projanr-50581"/>
            <funder ref="#projanr-34180"/>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2021-11-16 17:09:03</date>
              <date type="whenModified">2025-08-22 14:44:02</date>
              <date type="whenReleased">2021-11-22 09:16:24</date>
              <date type="whenProduced">2021-11-26</date>
              <date type="whenEndEmbargoed">2021-11-16</date>
              <ref type="file" target="https://hal.science/hal-03424056v1/document">
                <date notBefore="2021-11-16"/>
              </ref>
              <ref type="file" subtype="author" n="1" target="https://hal.science/hal-03424056v1/file/38711_0_merged_1620649111.pdf" id="file-3431519-3008781">
                <date notBefore="2021-11-16"/>
              </ref>
              <ref type="externalLink" target="https://hal.archives-ouvertes.fr/hal-03424056/document"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="97370">
                <persName>
                  <forename>Natacha</forename>
                  <surname>Rochel</surname>
                </persName>
                <email type="md5">ab3cf19f82949b7aff218dfc351b11dd</email>
                <email type="domain">igbmc.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-03424056</idno>
            <idno type="halUri">https://hal.science/hal-03424056</idno>
            <idno type="halBibtex">germain:hal-03424056</idno>
            <idno type="halRefHtml">&lt;i&gt;Essays in Biochemistry&lt;/i&gt;, 2021, 65 (6), pp.887-899. &lt;a target="_blank" href="https://dx.doi.org/10.1042/EBC20200168"&gt;&amp;#x27E8;10.1042/EBC20200168&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Essays in Biochemistry, 2021, 65 (6), pp.887-899. &amp;#x27E8;10.1042/EBC20200168&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://about.hal.science/hal-authorisation-v1/">HAL Authorization<ref corresp="#file-3431519-3008781"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="IGBMC" corresp="INSERM">Institut Génétique de Biologie Moléculaire et Cellulaire</idno>
            <idno type="stamp" n="CBS">Centre de biochimie structurale</idno>
            <idno type="stamp" n="UNIV-STRASBG">Université de Strasbourg</idno>
            <idno type="stamp" n="BS">Biologie-Santé</idno>
            <idno type="stamp" n="UNIV-MONTPELLIER">Université de Montpellier</idno>
            <idno type="stamp" n="SITE-ALSACE">Archive ouverte du site Alsace</idno>
            <idno type="stamp" n="ANR">ANR</idno>
            <idno type="stamp" n="UM-2015-2021" corresp="UNIV-MONTPELLIER">Université de Montpellier (2015-2021)</idno>
            <idno type="stamp" n="UNIVOAK">UNIVOAK</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Ligands and DNA in the allosteric control of retinoid receptors function</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Pierre</forename>
                    <surname>Germain</surname>
                  </persName>
                  <email type="md5">0488d2a7fab83238a3c11329c7164f17</email>
                  <email type="domain">cbs.cnrs.fr</email>
                  <idno type="idhal" notation="numeric">1235972</idno>
                  <idno type="halauthorid" notation="string">102165-1235972</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-2962-9593</idno>
                  <affiliation ref="#struct-59411"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Natacha</forename>
                    <surname>Rochel</surname>
                  </persName>
                  <email type="md5">ab3cf19f82949b7aff218dfc351b11dd</email>
                  <email type="domain">igbmc.fr</email>
                  <idno type="idhal" notation="string">natacha-rochel</idno>
                  <idno type="idhal" notation="numeric">740505</idno>
                  <idno type="halauthorid" notation="string">5579-740505</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-3573-5889</idno>
                  <idno type="IDREF">https://www.idref.fr/183592468</idno>
                  <affiliation ref="#struct-93800"/>
                </author>
                <author role="crp">
                  <persName>
                    <forename type="first">William</forename>
                    <surname>Bourguet</surname>
                  </persName>
                  <email type="md5">1c3ccb966cad149ed3a0330296a9cbab</email>
                  <email type="domain">cbs.cnrs.fr</email>
                  <idno type="idhal" notation="string">william-bourguet</idno>
                  <idno type="idhal" notation="numeric">758185</idno>
                  <idno type="halauthorid" notation="string">213347-758185</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-0643-7719</idno>
                  <idno type="IDREF">https://www.idref.fr/084740191</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/I-5569-2013</idno>
                  <affiliation ref="#struct-59411"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">22285</idno>
                <idno type="issn">0071-1365</idno>
                <title level="j">Essays in Biochemistry</title>
                <imprint>
                  <publisher>Portland Press</publisher>
                  <biblScope unit="volume">65</biblScope>
                  <biblScope unit="issue">6</biblScope>
                  <biblScope unit="pp">887-899</biblScope>
                  <date type="datePub">2021-11-26</date>
                  <date type="dateEpub">2021-07-23</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1042/EBC20200168</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">retinoids</term>
                <term xml:lang="en">allosteric regulation</term>
                <term xml:lang="en">transcription</term>
                <term xml:lang="en">retinoids</term>
                <term xml:lang="en">retinoic acid receptor</term>
                <term xml:lang="en">retinoids</term>
              </keywords>
              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Retinoids are a family of compounds that include both vitamin A (all-trans retinol) and its naturally occurring metabolites such as retinoic acids (e.g. all-trans retinoic acid) as well as synthetic analogs. They are critically involved in the regulation of a wide variety of essential biological processes, such as embryogenesis and organogenesis, apoptosis, reproduction, vision, and the growth and differentiation of normal and neoplastic cells in vertebrates. The ability of these small molecules to control the expression of several hundred genes through binding to nuclear ligand-dependent transcription factors accounts for most of their functions. Three retinoic acid receptor (RARα,β,γ) and three retinoid X receptor (RXRα,β,γ) subtypes form a variety of RXR–RAR heterodimers that have been shown to mediate the pleiotropic effects of retinoids through the recruitment of high-molecular weight co-regulatory complexes to response-element DNA sequences found in the promoter region of their target genes. Hence, heterodimeric retinoid receptors are multidomain entities that respond to various incoming signals, such as ligand and DNA binding, by allosteric structural alterations which are the basis of further signal propagation. Here, we provide an overview of the current state of knowledge with regard to the structural mechanisms by which retinoids and DNA response elements act as allosteric effectors that may combine to finely tune RXR–RAR heterodimers activity.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-59411" status="OLD">
          <idno type="ISNI">0000000406391954</idno>
          <idno type="RNSR">200717455X</idno>
          <idno type="ROR">https://ror.org/0189yvq06</idno>
          <orgName>Centre de Biochimie Structurale [Montpellier]</orgName>
          <orgName type="acronym">CBS</orgName>
          <date type="start">1999-01-01</date>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <addrLine>29 rue de Navacelles 34090 Montpellier Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.cbs.cnrs.fr/</ref>
          </desc>
          <listRelation>
            <relation name="U1054" active="#struct-303623" type="direct"/>
            <relation active="#struct-410122" type="direct"/>
            <relation name="UMR5048" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-93800" status="VALID">
          <idno type="IdRef">155263749</idno>
          <idno type="ISNI">0000 0004 0638 2716</idno>
          <idno type="RNSR">200112491C</idno>
          <idno type="ROR">https://ror.org/0015ws592</idno>
          <idno type="Wikidata">Q3152004</idno>
          <orgName>Institut de Génétique et de Biologie Moléculaire et Cellulaire</orgName>
          <orgName type="acronym">IGBMC</orgName>
          <date type="start">2009-01-01</date>
          <desc>
            <address>
              <addrLine>Parc D'Innovation 1 Rue Laurent Fries - BP 10142 67404 Illkirch Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.igbmc.fr/</ref>
          </desc>
          <listRelation>
            <relation name="UMRS964" active="#struct-199013" type="direct"/>
            <relation name="U1258" active="#struct-303623" type="direct"/>
            <relation name="UMR7104" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-410122" status="OLD">
          <idno type="ISNI">0000000120970141</idno>
          <idno type="ROR">https://ror.org/051escj72</idno>
          <orgName>Université de Montpellier</orgName>
          <orgName type="acronym">UM</orgName>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <addrLine>163 rue Auguste Broussonnet - 34090 Montpellier</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.umontpellier.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-199013" status="VALID">
          <idno type="IdRef">131056549</idno>
          <idno type="ROR">https://ror.org/00pg6eq24</idno>
          <orgName>Université de Strasbourg</orgName>
          <orgName type="acronym">UNISTRA</orgName>
          <desc>
            <address>
              <addrLine>4 rue Blaise Pascal - CS 90032 - 67081 Strasbourg cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.unistra.fr/</ref>
          </desc>
        </org>
      </listOrg>
      <listOrg type="projects">
        <org type="anrProject" xml:id="projanr-50581" status="VALID">
          <idno type="anr">ANR-10-INBS-0005</idno>
          <orgName>FRISBI</orgName>
          <desc>Infrastructure Française pour la Biologie Structurale Intégrée</desc>
          <date type="start">2010</date>
        </org>
        <org type="anrProject" xml:id="projanr-34180" status="VALID">
          <idno type="anr">ANR-11-BSV8-0023</idno>
          <idno type="program">BLANC</idno>
          <orgName>RAR-SCALES</orgName>
          <desc>Relations structure-fonction des récepteurs à l'acide rétinoïque, du génomique à l'échelle atomique</desc>
          <date type="start">2011</date>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>