<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-03423506</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-22T15:07:22+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">The equilibrative nucleoside transporter ENT1 is critical for nucleotide homeostasis and optimal erythropoiesis</title>
            <author role="aut">
              <persName>
                <forename type="first">Mahmoud</forename>
                <surname>Mikdar</surname>
              </persName>
              <idno type="idhal" notation="numeric">799269</idno>
              <idno type="halauthorid" notation="string">1754028-799269</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-3449-2851</idno>
              <affiliation ref="#struct-1005032"/>
              <affiliation ref="#struct-1005049"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Pedro</forename>
                <surname>González-Menéndez</surname>
              </persName>
              <email type="md5">4f13c88ed2716437c223c382b8c06f57</email>
              <email type="domain">uniovi.es</email>
              <idno type="idhal" notation="numeric">814118</idno>
              <idno type="halauthorid" notation="string">2334220-814118</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-3114-6304</idno>
              <affiliation ref="#struct-1005049"/>
              <affiliation ref="#struct-1077717"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Xiaoli</forename>
                <surname>Cai</surname>
              </persName>
              <idno type="halauthorid">2334221-0</idno>
              <affiliation ref="#struct-303979"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Yujin</forename>
                <surname>Zhang</surname>
              </persName>
              <idno type="halauthorid">2334222-0</idno>
              <affiliation ref="#struct-303979"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Marion</forename>
                <surname>Serra</surname>
              </persName>
              <idno type="halauthorid">2137362-0</idno>
              <affiliation ref="#struct-1005032"/>
              <affiliation ref="#struct-1005049"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Abdoul</forename>
                <surname>Dembele</surname>
              </persName>
              <idno type="halauthorid">2334223-0</idno>
              <affiliation ref="#struct-1005032"/>
              <affiliation ref="#struct-1005049"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Anne-Claire</forename>
                <surname>Boschat</surname>
              </persName>
              <idno type="idhal" notation="numeric">795717</idno>
              <idno type="halauthorid" notation="string">1623112-795717</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-9535-9435</idno>
              <idno type="IDREF">https://www.idref.fr/248588079</idno>
              <affiliation ref="#struct-1004662"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Sylvia</forename>
                <surname>Sanquer</surname>
              </persName>
              <idno type="idhal" notation="numeric">794593</idno>
              <idno type="halauthorid" notation="string">1557513-794593</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-0347-6501</idno>
              <affiliation ref="#struct-1004846"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Cerina</forename>
                <surname>Chhuon</surname>
              </persName>
              <idno type="idhal" notation="numeric">1277850</idno>
              <idno type="halauthorid" notation="string">1056796-1277850</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-1347-7492</idno>
              <affiliation ref="#struct-1004805"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Ida Chiara</forename>
                <surname>Guerrera</surname>
              </persName>
              <email type="md5">a79e5a55e507b98b84b9da4152bafca2</email>
              <email type="domain">inserm.fr</email>
              <idno type="idhal" notation="numeric">792780</idno>
              <idno type="halauthorid" notation="string">1108947-792780</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-4832-6793</idno>
              <idno type="IDREF">https://www.idref.fr/200820249</idno>
              <idno type="VIAF">https://viaf.org/viaf/284149717630110952249</idno>
              <affiliation ref="#struct-1004805"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Marc</forename>
                <surname>Sitbon</surname>
              </persName>
              <email type="md5">9360bda2579b665d97e1078112b66b0a</email>
              <email type="domain">igmm.cnrs.fr</email>
              <idno type="idhal" notation="string">marc-sitbon</idno>
              <idno type="idhal" notation="numeric">174563</idno>
              <idno type="halauthorid" notation="string">13160-174563</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-3616-2338</idno>
              <idno type="GOOGLE SCHOLAR">https://scholar.google.com/citations?user=deo3RdgAAAAJ&amp;hl=en&amp;authuser=1</idno>
              <idno type="IDREF">https://www.idref.fr/095075259</idno>
              <affiliation ref="#struct-1077717"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Olivier</forename>
                <surname>Hermine</surname>
              </persName>
              <email type="md5">1a1f9d1cbc8929064a46879b0012d4c0</email>
              <email type="domain">necker.fr</email>
              <idno type="idhal" notation="numeric">1308844</idno>
              <idno type="halauthorid" notation="string">221030-1308844</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-2574-3874</idno>
              <idno type="IDREF">https://www.idref.fr/069884927</idno>
              <idno type="VIAF">https://viaf.org/viaf/190586086</idno>
              <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=l2vRMWkAAAAJ</idno>
              <affiliation ref="#struct-1005049"/>
              <affiliation ref="#struct-1288"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Yves</forename>
                <surname>Colin</surname>
              </persName>
              <idno type="idhal" notation="numeric">757927</idno>
              <idno type="halauthorid" notation="string">203633-757927</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-5196-4254</idno>
              <idno type="IDREF">https://www.idref.fr/090180755</idno>
              <affiliation ref="#struct-1005032"/>
              <affiliation ref="#struct-1005049"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Caroline</forename>
                <surname>Le van Kim</surname>
              </persName>
              <idno type="idhal" notation="numeric">757928</idno>
              <idno type="halauthorid" notation="string">203634-757928</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-3251-1310</idno>
              <idno type="IDREF">https://www.idref.fr/113048041</idno>
              <affiliation ref="#struct-1005032"/>
              <affiliation ref="#struct-1005049"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Sandrina</forename>
                <surname>Kinet</surname>
              </persName>
              <email type="md5">96c1f4da2ee6c89e0b7908df1ee16a1e</email>
              <email type="domain">igmm.cnrs.fr</email>
              <idno type="idhal" notation="string">sandrina-kinet</idno>
              <idno type="idhal" notation="numeric">740239</idno>
              <idno type="halauthorid" notation="string">8022-740239</idno>
              <idno type="IDREF">https://www.idref.fr/195695437</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-0699-108X</idno>
              <affiliation ref="#struct-1005049"/>
              <affiliation ref="#struct-1077717"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Narla</forename>
                <surname>Mohandas</surname>
              </persName>
              <idno type="idhal" notation="numeric">762283</idno>
              <idno type="halauthorid" notation="string">444038-762283</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-2271-5296</idno>
              <affiliation ref="#struct-345810"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Yang</forename>
                <surname>Xia</surname>
              </persName>
              <idno type="idhal" notation="numeric">772414</idno>
              <idno type="halauthorid" notation="string">863390-772414</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-8059-6179</idno>
              <affiliation ref="#struct-303979"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Thierry</forename>
                <surname>Peyrard</surname>
              </persName>
              <idno type="idhal" notation="numeric">763616</idno>
              <idno type="halauthorid" notation="string">518640-763616</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-7715-568X</idno>
              <idno type="IDREF">https://www.idref.fr/162423713</idno>
              <affiliation ref="#struct-1005032"/>
              <affiliation ref="#struct-1005049"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Naomi</forename>
                <surname>Taylor</surname>
              </persName>
              <email type="md5">a9564451a464044836e60608e4ba19a0</email>
              <email type="domain">igmm.cnrs.fr</email>
              <idno type="idhal" notation="numeric">857337</idno>
              <idno type="halauthorid" notation="string">178190-857337</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-2459-4558</idno>
              <idno type="IDREF">https://www.idref.fr/069480672</idno>
              <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=pEgqdPYAAAAJ</idno>
              <idno type="VIAF">https://viaf.org/viaf/214130755</idno>
              <affiliation ref="#struct-1077717"/>
              <affiliation ref="#struct-1005049"/>
              <affiliation ref="#struct-1182789"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Slim</forename>
                <surname>Azouzi</surname>
              </persName>
              <idno type="idhal" notation="numeric">780189</idno>
              <idno type="halauthorid" notation="string">1099081-780189</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-5519-4031</idno>
              <affiliation ref="#struct-1005032"/>
              <affiliation ref="#struct-1005049"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Mélanie</forename>
                <surname>KARLI</surname>
              </persName>
              <email type="md5">ede2b723a0c0ac40035aa4ead502961c</email>
              <email type="domain">umontpellier.fr</email>
            </editor>
            <funder ref="#projanr-50423"/>
            <funder ref="#projanr-54935"/>
            <funder>This work is also supported by grants from the Fondation Recherche Médicale (N.T.), National Institutes of Health (NIH) National Institute of Diabètes and Digestive and Kidney Diseases (PO1 DK032094) (M.N., S.K., and N.T.), NIH National Heart, Lung, and Blood Institute (HL137990 and HL136969) (Y.X.), and the McGovern Fund at the University of Texas Health Science Center-McGovern Medical School (Y.X.). M.M. was funded by the Ministère de l’Enseignement Supérieur et de la Recherche (École Doctorale BioSPC) and the Institut National de la Transfusion Sanguine. P.G.-M. was funded by the CLARIN-COFUND program from the Principado de Asturias and the European Union.</funder>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2021-11-17 09:37:41</date>
              <date type="whenModified">2026-05-12 03:18:30</date>
              <date type="whenReleased">2021-11-22 09:18:53</date>
              <date type="whenProduced">2021-06-24</date>
              <date type="whenEndEmbargoed">2022-01-24</date>
              <ref type="file" target="https://hal.science/hal-03423506v1/document">
                <date notBefore="2022-01-24"/>
              </ref>
              <ref type="file" subtype="author" n="1" target="https://hal.science/hal-03423506v1/file/Mikdar%20et%20al.pdf" id="file-3432076-3009349">
                <date notBefore="2022-01-24"/>
              </ref>
              <ref type="externalLink" target="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8225918"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="549666">
                <persName>
                  <forename>Mélanie</forename>
                  <surname>KARLI</surname>
                </persName>
                <email type="md5">ede2b723a0c0ac40035aa4ead502961c</email>
                <email type="domain">umontpellier.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-03423506</idno>
            <idno type="halUri">https://hal.science/hal-03423506</idno>
            <idno type="halBibtex">mikdar:hal-03423506</idno>
            <idno type="halRefHtml">&lt;i&gt;Blood&lt;/i&gt;, 2021, 137 (25), pp.3548-3562. &lt;a target="_blank" href="https://dx.doi.org/10.1182/blood.2020007281"&gt;&amp;#x27E8;10.1182/blood.2020007281&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Blood, 2021, 137 (25), pp.3548-3562. &amp;#x27E8;10.1182/blood.2020007281&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://about.hal.science/hal-authorisation-v1/">HAL Authorization<ref corresp="#file-3432076-3009349"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno>
            <idno type="stamp" n="UNIV-AG">Université des Antilles</idno>
            <idno type="stamp" n="AFRIQ">HAL-Francophonie, Afrique et océan indien</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="APHP" corresp="INSERM">AP-HP</idno>
            <idno type="stamp" n="IGMM">Institut de génétique moléculaire de Montpellier</idno>
            <idno type="stamp" n="BS">Biologie-Santé</idno>
            <idno type="stamp" n="UNIV-MONTPELLIER">Université de Montpellier</idno>
            <idno type="stamp" n="UNIV-PARIS">Université Paris Cité</idno>
            <idno type="stamp" n="UNIVERSITE-PARIS" corresp="UNIV-PARIS">Université Paris Cité</idno>
            <idno type="stamp" n="UP-SANTE">Université Paris Cité - Faculté de Santé</idno>
            <idno type="stamp" n="UP-SCIENCES">Université Paris Cité - Faculté des Sciences</idno>
            <idno type="stamp" n="ANR">ANR</idno>
            <idno type="stamp" n="UM-2015-2021" corresp="UNIV-MONTPELLIER">Université de Montpellier (2015-2021)</idno>
            <idno type="stamp" n="ACADEMIE-SCIENCES">Académie des sciences</idno>
            <idno type="stamp" n="BIGR">Biologie Intégrée du Globule Rouge et de l’Érythropoïèse  UMR-S 1134</idno>
            <idno type="stamp" n="ACADEMIE-SCIENCES-PUBLICATIONS-MEMBRES" corresp="ACADEMIE-SCIENCES">Publications des membres, correspondants et associés étrangers de l'Académie des sciences</idno>
            <idno type="stamp" n="ACADEMIE-SCIENCES-PUBLICATIONS-MEMBRES-3" corresp="ACADEMIE-SCIENCES-PUBLICATIONS-MEMBRES">Publications des membres de l'Académie des sciences (lot 3)</idno>
          </seriesStmt>
          <notesStmt>
            <note type="commentary">This is a related article to: Nucleoside ENTry modulates erythropoiesis (cf ci-dessous)</note>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">The equilibrative nucleoside transporter ENT1 is critical for nucleotide homeostasis and optimal erythropoiesis</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Mahmoud</forename>
                    <surname>Mikdar</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">799269</idno>
                  <idno type="halauthorid" notation="string">1754028-799269</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-3449-2851</idno>
                  <affiliation ref="#struct-1005032"/>
                  <affiliation ref="#struct-1005049"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Pedro</forename>
                    <surname>González-Menéndez</surname>
                  </persName>
                  <email type="md5">4f13c88ed2716437c223c382b8c06f57</email>
                  <email type="domain">uniovi.es</email>
                  <idno type="idhal" notation="numeric">814118</idno>
                  <idno type="halauthorid" notation="string">2334220-814118</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-3114-6304</idno>
                  <affiliation ref="#struct-1005049"/>
                  <affiliation ref="#struct-1077717"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Xiaoli</forename>
                    <surname>Cai</surname>
                  </persName>
                  <idno type="halauthorid">2334221-0</idno>
                  <affiliation ref="#struct-303979"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Yujin</forename>
                    <surname>Zhang</surname>
                  </persName>
                  <idno type="halauthorid">2334222-0</idno>
                  <affiliation ref="#struct-303979"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Marion</forename>
                    <surname>Serra</surname>
                  </persName>
                  <idno type="halauthorid">2137362-0</idno>
                  <affiliation ref="#struct-1005032"/>
                  <affiliation ref="#struct-1005049"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Abdoul</forename>
                    <surname>Dembele</surname>
                  </persName>
                  <idno type="halauthorid">2334223-0</idno>
                  <affiliation ref="#struct-1005032"/>
                  <affiliation ref="#struct-1005049"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Anne-Claire</forename>
                    <surname>Boschat</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">795717</idno>
                  <idno type="halauthorid" notation="string">1623112-795717</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-9535-9435</idno>
                  <idno type="IDREF">https://www.idref.fr/248588079</idno>
                  <affiliation ref="#struct-1004662"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Sylvia</forename>
                    <surname>Sanquer</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">794593</idno>
                  <idno type="halauthorid" notation="string">1557513-794593</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-0347-6501</idno>
                  <affiliation ref="#struct-1004846"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Cerina</forename>
                    <surname>Chhuon</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1277850</idno>
                  <idno type="halauthorid" notation="string">1056796-1277850</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-1347-7492</idno>
                  <affiliation ref="#struct-1004805"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Ida Chiara</forename>
                    <surname>Guerrera</surname>
                  </persName>
                  <email type="md5">a79e5a55e507b98b84b9da4152bafca2</email>
                  <email type="domain">inserm.fr</email>
                  <idno type="idhal" notation="numeric">792780</idno>
                  <idno type="halauthorid" notation="string">1108947-792780</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-4832-6793</idno>
                  <idno type="IDREF">https://www.idref.fr/200820249</idno>
                  <idno type="VIAF">https://viaf.org/viaf/284149717630110952249</idno>
                  <affiliation ref="#struct-1004805"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Marc</forename>
                    <surname>Sitbon</surname>
                  </persName>
                  <email type="md5">9360bda2579b665d97e1078112b66b0a</email>
                  <email type="domain">igmm.cnrs.fr</email>
                  <idno type="idhal" notation="string">marc-sitbon</idno>
                  <idno type="idhal" notation="numeric">174563</idno>
                  <idno type="halauthorid" notation="string">13160-174563</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-3616-2338</idno>
                  <idno type="GOOGLE SCHOLAR">https://scholar.google.com/citations?user=deo3RdgAAAAJ&amp;hl=en&amp;authuser=1</idno>
                  <idno type="IDREF">https://www.idref.fr/095075259</idno>
                  <affiliation ref="#struct-1077717"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Olivier</forename>
                    <surname>Hermine</surname>
                  </persName>
                  <email type="md5">1a1f9d1cbc8929064a46879b0012d4c0</email>
                  <email type="domain">necker.fr</email>
                  <idno type="idhal" notation="numeric">1308844</idno>
                  <idno type="halauthorid" notation="string">221030-1308844</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-2574-3874</idno>
                  <idno type="IDREF">https://www.idref.fr/069884927</idno>
                  <idno type="VIAF">https://viaf.org/viaf/190586086</idno>
                  <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=l2vRMWkAAAAJ</idno>
                  <affiliation ref="#struct-1005049"/>
                  <affiliation ref="#struct-1288"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Yves</forename>
                    <surname>Colin</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">757927</idno>
                  <idno type="halauthorid" notation="string">203633-757927</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-5196-4254</idno>
                  <idno type="IDREF">https://www.idref.fr/090180755</idno>
                  <affiliation ref="#struct-1005032"/>
                  <affiliation ref="#struct-1005049"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Caroline</forename>
                    <surname>Le van Kim</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">757928</idno>
                  <idno type="halauthorid" notation="string">203634-757928</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-3251-1310</idno>
                  <idno type="IDREF">https://www.idref.fr/113048041</idno>
                  <affiliation ref="#struct-1005032"/>
                  <affiliation ref="#struct-1005049"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Sandrina</forename>
                    <surname>Kinet</surname>
                  </persName>
                  <email type="md5">96c1f4da2ee6c89e0b7908df1ee16a1e</email>
                  <email type="domain">igmm.cnrs.fr</email>
                  <idno type="idhal" notation="string">sandrina-kinet</idno>
                  <idno type="idhal" notation="numeric">740239</idno>
                  <idno type="halauthorid" notation="string">8022-740239</idno>
                  <idno type="IDREF">https://www.idref.fr/195695437</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-0699-108X</idno>
                  <affiliation ref="#struct-1005049"/>
                  <affiliation ref="#struct-1077717"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Narla</forename>
                    <surname>Mohandas</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">762283</idno>
                  <idno type="halauthorid" notation="string">444038-762283</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-2271-5296</idno>
                  <affiliation ref="#struct-345810"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Yang</forename>
                    <surname>Xia</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">772414</idno>
                  <idno type="halauthorid" notation="string">863390-772414</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-8059-6179</idno>
                  <affiliation ref="#struct-303979"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Thierry</forename>
                    <surname>Peyrard</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">763616</idno>
                  <idno type="halauthorid" notation="string">518640-763616</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-7715-568X</idno>
                  <idno type="IDREF">https://www.idref.fr/162423713</idno>
                  <affiliation ref="#struct-1005032"/>
                  <affiliation ref="#struct-1005049"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Naomi</forename>
                    <surname>Taylor</surname>
                  </persName>
                  <email type="md5">a9564451a464044836e60608e4ba19a0</email>
                  <email type="domain">igmm.cnrs.fr</email>
                  <idno type="idhal" notation="numeric">857337</idno>
                  <idno type="halauthorid" notation="string">178190-857337</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-2459-4558</idno>
                  <idno type="IDREF">https://www.idref.fr/069480672</idno>
                  <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=pEgqdPYAAAAJ</idno>
                  <idno type="VIAF">https://viaf.org/viaf/214130755</idno>
                  <affiliation ref="#struct-1077717"/>
                  <affiliation ref="#struct-1005049"/>
                  <affiliation ref="#struct-1182789"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Slim</forename>
                    <surname>Azouzi</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">780189</idno>
                  <idno type="halauthorid" notation="string">1099081-780189</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-5519-4031</idno>
                  <affiliation ref="#struct-1005032"/>
                  <affiliation ref="#struct-1005049"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">11250</idno>
                <idno type="issn">0006-4971</idno>
                <idno type="eissn">1528-0020</idno>
                <title level="j">Blood</title>
                <imprint>
                  <publisher>American Society of Hematology</publisher>
                  <biblScope unit="volume">137</biblScope>
                  <biblScope unit="issue">25</biblScope>
                  <biblScope unit="pp">3548-3562</biblScope>
                  <date type="datePub">2021-06-24</date>
                  <date type="dateEpub">2021-03-10</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1182/blood.2020007281</idno>
              <idno type="pubmed">33690842</idno>
              <idno type="pubmedcentral">PMC8225918</idno>
              <ref target="https://ashpublications.org/blood/article/137/25/3468/476206/Nucleoside-ENTry-modulates-erythropoiesis" type="seeAlso"/>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>The tight regulation of intracellular nucleotides is critical for the self-renewal and lineage specification of hematopoietic stem cells (HSCs). Nucleosides are major metabolite precursors for nucleotide biosynthesis and their availability in HSCs is dependent on their transport through specific membrane transporters. However, the role of nucleoside transporters in the differentiation of HSCs to the erythroid lineage and in red cell biology remains to be fully defined. Here, we show that the absence of the equilibrative nucleoside transporter (ENT1) in human red blood cells with a rare Augustine-null blood type is associated with macrocytosis, anisopoikilocytosis, an abnormal nucleotide metabolome, and deregulated protein phosphorylation. A specific role for ENT1 in human erythropoiesis was demonstrated by a defective erythropoiesis of human CD34+ progenitors following short hairpin RNA-mediated knockdown of ENT1. Furthermore, genetic deletion of ENT1 in mice was associated with reduced erythroid progenitors in the bone marrow, anemia, and macrocytosis. Mechanistically, we found that ENT1-mediated adenosine transport is critical for cyclic adenosine monophosphate homeostasis and the regulation of erythroid transcription factors. Notably, genetic investigation of 2 ENT1null individuals demonstrated a compensation by a loss-of-function variant in the ABCC4 cyclic nucleotide exporter. Indeed, pharmacological inhibition of ABCC4 in Ent1−/− mice rescued erythropoiesis. Overall, our results highlight the importance of ENT1-mediated nucleotide metabolism in erythropoiesis.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-1005032" status="VALID">
          <idno type="IdRef">225640988</idno>
          <idno type="RNSR">201420734F</idno>
          <orgName>Biologie Intégrée du Globule Rouge</orgName>
          <orgName type="acronym">BIGR (UMR_S_1134 / U1134)</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>6 rue Alexandre Cabanel - 75739 Paris cedex 15</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.u1134.inserm.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-266750" type="direct"/>
            <relation active="#struct-300316" type="direct"/>
            <relation name="U1134" active="#struct-303623" type="direct"/>
            <relation active="#struct-328176" type="direct"/>
            <relation active="#struct-524399" type="direct"/>
            <relation name="UMR_S_1134" active="#struct-557826" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-1005049" status="VALID">
          <orgName>Laboratoire d'Excellence : Biogenèse et pathologies du globule rouge</orgName>
          <orgName type="acronym">Labex Gr-Ex</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>Imagine Institute24, Boulevard du Montparnasse75015, Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.labex-grex.com/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-303171" type="direct"/>
            <relation active="#struct-303623" type="direct"/>
            <relation active="#struct-557826" type="direct"/>
          </listRelation>
        </org>
        <org type="researchteam" xml:id="struct-1077717" status="OLD">
          <orgName>Hematopoïèse et Immunothérapie</orgName>
          <date type="start">2011-09-01</date>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-712" type="direct"/>
            <relation active="#struct-410122" type="indirect"/>
            <relation name="UMR5535 / UMR9942" active="#struct-441569" type="indirect"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-303979" status="VALID">
          <idno type="ROR">https://ror.org/03gds6c39</idno>
          <orgName>The University of Texas Health Science Center at Houston</orgName>
          <orgName type="acronym">UTHealth</orgName>
          <desc>
            <address>
              <addrLine>7000 Fannin, Suite 1200Houston, Texas 77030</addrLine>
              <country key="US"/>
            </address>
            <ref type="url">https://www.uth.edu/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-1004662" status="VALID">
          <idno type="IdRef">188538119</idno>
          <idno type="ISNI">0000 0004 0620 6624</idno>
          <idno type="RNSR">201420829J</idno>
          <idno type="ROR">https://ror.org/04z4fen17</idno>
          <orgName>Imagine - Institut des maladies génétiques (IHU)</orgName>
          <orgName type="acronym">Imagine - U1163</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>IHU Imagine, 156 rue de Vaugirard, 75015 PARIS et 24 Boulevard du Montparnasse, 75015 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.institutimagine.org/fr/</ref>
          </desc>
          <listRelation>
            <relation name="U1163" active="#struct-303623" type="direct"/>
            <relation name="UMR_S 1163" active="#struct-557826" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-1004846" status="OLD">
          <idno type="IdRef">174964552</idno>
          <idno type="RNSR">200616420B</idno>
          <orgName>Toxicité environnementale, cibles thérapeutiques, signalisation cellulaire</orgName>
          <orgName type="acronym">T3S - UMR_S 1124</orgName>
          <date type="start">2020-01-01</date>
          <date type="end">2024-12-31</date>
          <desc>
            <address>
              <addrLine>Centre Universitaire des Saints Pères - 45 Rue des Saints-Pères 75270 Paris Cedex 06</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://umrs1124.biomedicale.parisdescartes.fr/</ref>
          </desc>
          <listRelation>
            <relation name="U1124" active="#struct-303623" type="direct"/>
            <relation name="UMR_S 1124" active="#struct-557826" type="direct"/>
          </listRelation>
        </org>
        <org type="researchteam" xml:id="struct-1004805" status="VALID">
          <orgName>Plateforme Protéomique Necker [SFR Necker]</orgName>
          <orgName type="acronym">PPN - 3P5</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>Site Necker : 156 rue du Vaugirard- 75015 Paris- Bâtiment Hamburger et bâtiment Lavoisier.Site Broussais : 14 Rue Maria Helena Vieira Da Silva, CS61431- 75993 Paris cedex 14- Bâtiment Leriche.</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.necker.fr/sfr-necker/index.php?menu=platforms&amp;faculty_id=11</ref>
          </desc>
          <listRelation>
            <relation active="#struct-1004800" type="direct"/>
            <relation active="#struct-300068" type="indirect"/>
            <relation name="US24" active="#struct-303623" type="indirect"/>
            <relation name="UAR3633 / UMS3633" active="#struct-441569" type="indirect"/>
            <relation name="UMS 3633" active="#struct-557826" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-1288" status="OLD">
          <idno type="RNSR">200412803D</idno>
          <orgName>Cytokines, hématopoïèse et réponse immune</orgName>
          <orgName type="acronym">CHRI</orgName>
          <date type="start">2004-01-01</date>
          <date type="end">2014-12-31</date>
          <desc>
            <address>
              <addrLine>Bâtiment Sèvres - Porte I 161 Rue de Sèvres 75743 PARIS CEDEX 15</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation name="UMR 8147" active="#struct-301664" type="direct"/>
            <relation name="UMR 8147" active="#struct-303623" type="direct"/>
            <relation name="UMR8147" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-345810" status="VALID">
          <idno type="ROR">https://ror.org/01xvcf081</idno>
          <orgName>New York Blood Center</orgName>
          <desc>
            <address>
              <addrLine>310 E 67th StNew York, NY 10065</addrLine>
              <country key="US"/>
            </address>
            <ref type="url">https://nybloodcenter.org/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-1182789" status="VALID">
          <idno type="IdRef">027215156</idno>
          <idno type="ISNI">0000000119420345</idno>
          <idno type="ROR">https://ror.org/01cwqze88</idno>
          <idno type="Wikidata">Q390551</idno>
          <orgName>National Institutes of Health [Bethesda, MD, USA]</orgName>
          <orgName type="acronym">NIH</orgName>
          <desc>
            <address>
              <addrLine>9000 Rockville Pike, Bethesda, Maryland 20892, USA</addrLine>
              <country key="US"/>
            </address>
            <ref type="url">https://www.nih.gov/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-266750" status="VALID">
          <idno type="ROR">https://ror.org/00fh58138</idno>
          <orgName>Institut National de la Transfusion Sanguine [Paris]</orgName>
          <orgName type="acronym">INTS</orgName>
          <desc>
            <address>
              <addrLine>6 rue Alexandre Cabanel, 75739 Paris cedex 15</addrLine>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300316" status="VALID">
          <idno type="IdRef">026404451</idno>
          <idno type="ISNI">0000000121112608</idno>
          <idno type="ROR">https://ror.org/005ypkf75</idno>
          <orgName>Université de La Réunion</orgName>
          <orgName type="acronym">UR</orgName>
          <date type="start">1982-10-15</date>
          <desc>
            <address>
              <addrLine>15, avenue René Cassin - CS92003 -97744 Saint Denis Cedex 9</addrLine>
              <country key="RE"/>
            </address>
            <ref type="url">http://www.univ-reunion.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-328176" status="VALID">
          <idno type="ROR">https://ror.org/04sfmcd28</idno>
          <orgName>CHU Pointe-à-Pitre / Abymes [Guadeloupe]</orgName>
          <desc>
            <address>
              <addrLine>Route de Chauvel - BP 465 - 97159 Pointe-à-Pitre cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-guadeloupe.fr</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-524399" status="VALID">
          <idno type="IdRef">187841578</idno>
          <idno type="ROR">https://ror.org/02ryfmr77</idno>
          <orgName>Université des Antilles</orgName>
          <orgName type="acronym">UA</orgName>
          <date type="start">2015-01-01</date>
          <desc>
            <address>
              <addrLine>Université des Antilles | Fouillole - BP 250 - 97157 Pointe-à-Pitre</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-antilles.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-557826" status="VALID">
          <idno type="IdRef">236453505</idno>
          <idno type="ISNI">0000 0004 7885 7602</idno>
          <idno type="ROR">https://ror.org/05f82e368</idno>
          <orgName>Université Paris Cité</orgName>
          <orgName type="acronym">UPCité</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>85 boulevard Saint-Germain75006 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://u-paris.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-303171" status="VALID">
          <idno type="IdRef">19077990X</idno>
          <idno type="ROR">https://ror.org/001z21q04</idno>
          <orgName>Université Sorbonne Paris Cité</orgName>
          <orgName type="acronym">USPC</orgName>
          <date type="start">2010-01-01</date>
          <desc>
            <address>
              <addrLine>Université Sorbonne Paris Cité | 100-104, avenue de France | 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.sorbonne-paris-cite.fr/fr</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-712" status="OLD">
          <idno type="ISNI">0000000405990285</idno>
          <idno type="RNSR">199111979P</idno>
          <idno type="ROR">https://ror.org/02785qs39</idno>
          <orgName>Institut de Génétique Moléculaire de Montpellier</orgName>
          <orgName type="acronym">IGMM</orgName>
          <date type="start">1993-01-01</date>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <addrLine>1919 Route de Mende - 34293 Montpellier Cedex 5</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.igmm.cnrs.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-410122" type="direct"/>
            <relation name="UMR5535 / UMR9942" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-410122" status="OLD">
          <idno type="ISNI">0000000120970141</idno>
          <idno type="ROR">https://ror.org/051escj72</idno>
          <orgName>Université de Montpellier</orgName>
          <orgName type="acronym">UM</orgName>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <addrLine>163 rue Auguste Broussonnet - 34090 Montpellier</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.umontpellier.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-1004800" status="VALID">
          <idno type="ISNI">0000000405939113</idno>
          <idno type="RNSR">201420835R</idno>
          <idno type="ROR">https://ror.org/05tr67282</idno>
          <orgName>Structure Fédérative de Recherche Necker</orgName>
          <orgName type="acronym">UAR 3633 / US24</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>14 rue Maria Da Silva CS61431 75014 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.necker.fr/sfr-necker/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300068" type="direct"/>
            <relation name="US24" active="#struct-303623" type="direct"/>
            <relation name="UAR3633 / UMS3633" active="#struct-441569" type="direct"/>
            <relation name="UMS 3633" active="#struct-557826" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-300068" status="VALID">
          <idno type="ROR">https://ror.org/00pg5jh14</idno>
          <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
          <orgName type="acronym">AP-HP</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-301664" status="OLD">
          <idno type="IdRef">026404788</idno>
          <idno type="ISNI">0000 0001 2188 0914 </idno>
          <idno type="ROR">https://ror.org/0220k9r37</idno>
          <orgName>Université Paris Descartes - Paris 5</orgName>
          <orgName type="acronym">UPD5</orgName>
          <date type="start">1971-01-01</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>12, rue de l'École de Médecine - 75270 Paris cedex 06</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.parisdescartes.fr/</ref>
          </desc>
        </org>
      </listOrg>
      <listOrg type="projects">
        <org type="anrProject" xml:id="projanr-50423" status="VALID">
          <idno type="anr">ANR-18-IDEX-0001</idno>
          <orgName>Université de Paris</orgName>
          <desc>Université de Paris</desc>
          <date type="start">2018</date>
        </org>
        <org type="anrProject" xml:id="projanr-54935" status="VALID">
          <idno type="anr">ANR-11-LABX-0051</idno>
          <orgName>GR-Ex</orgName>
          <desc>Biogenèse et pathologies du globule rouge</desc>
          <date type="start">2011</date>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>