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Article Dans Une Revue Nature Communications Année : 2022

SWI/SNF chromatin remodeler complex within the reward pathway is required for behavioral adaptations to stress

Peter Vanhoutte
Sébastien Parnaudeau
  • Fonction : co dernier-auteur

Résumé

Enduring behavioral changes upon stress exposure involve changes in gene expression sustained by epigenetic modifications in brain circuits, including the mesocorticolimbic pathway. Brahma (BRM) and Brahma Related Gene 1 (BRG1) are ATPase subunits of the SWI/SNF complexes involved in chromatin remodeling, a process essential to enduring plastic changes in gene expression. Here, we show that in mice, social defeat induces changes in BRG1 nuclear distribution. The inactivation of the Brg1/Smarca4 gene within dopamine-innervated regions or the constitutive inactivation of the Brm/Smarca2 gene leads to resilience to repeated social defeat and decreases the behavioral responses to cocaine without impacting midbrain dopamine neurons activity. Within striatal medium spiny neurons, Brg1 gene inactivation reduces the expression of stress-and cocaine-induced immediate early genes, increases levels of heterochromatin and at a global scale decreases chromatin accessibility. Altogether these data demonstrate the pivotal function of SWI/SNF complexes in behavioral and transcriptional adaptations to salient environmental challenges.
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hal-03823418 , version 1 (20-10-2022)

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Abdallah Zayed, Camille Baranowski, Anne-Claire Compagnion, Cécile Vernochet, Samah Karaki, et al.. SWI/SNF chromatin remodeler complex within the reward pathway is required for behavioral adaptations to stress. Nature Communications, 2022, 13 (1), pp.1807. ⟨10.1038/s41467-022-29380-8⟩. ⟨hal-03823418⟩
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