Organization of DNA in Mammalian Mitochondria - Archive ouverte HAL Accéder directement au contenu
Chapitre D'ouvrage Année : 2019

Organization of DNA in Mammalian Mitochondria

Géraldine Farge
Maria Falkenberg
  • Fonction : Auteur

Résumé

As with all organisms that must organize and condense their DNA to fit within the limited volume of a cell or a nucleus, mammalian mitochondrial DNA (mtDNA) is packaged into nucleoprotein structures called nucleoids. In this study, we first introduce the general modes of DNA compaction, especially the role of the nucleoid-associated proteins (NAPs) that structure the bacterial chromosome. We then present the mitochondrial nucleoid and the main factors responsible for packaging of mtDNA: ARS- (autonomously replicating sequence-) binding factor 2 protein (Abf2p) in yeast and mitochondrial transcription factor A (TFAM) in mammals. We summarize the single-molecule manipulation experiments on mtDNA compaction and visualization of mitochondrial nucleoids that have led to our current knowledge on mtDNA compaction. Lastly, we discuss the possible regulatory role of DNA packaging by TFAM in DNA transactions such as mtDNA replication and transcription.

Dates et versions

hal-03419513 , version 1 (08-11-2021)

Identifiants

Citer

Géraldine Farge, Maria Falkenberg. Organization of DNA in Mammalian Mitochondria. International Journal of Molecular Sciences, 20 (11), pp.2770, 2019, ⟨10.3390/ijms20112770⟩. ⟨hal-03419513⟩
30 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More