Towards the design, synthesis and preliminary biological evaluation of potential corono and clipcarbenes: Novel bis-imidazolium-bis-heterocycle macrocyclic ligands
Résumé
The synthesis of novel macrocyclic N-bis-imidazolium-bis-heterocyclic carbenes (NHCs) with rigid and constrained structures to improve the stability of their transition metal coordination complexes in order to obtain efficient photosensitizers is reported. Two pathways have been developed for the preparation of coronocarbenes (L1-L3) containing bipyridine or bithiazole groups. Flexible hemi-macrocycles with potential as clipcarbenes (L1″-L3″) are also described. The crystal structures of ligands L1 and L3 are detailed and the preliminary biological evaluation of L1-L3 is presented.
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