Hygrothermal properties of building materials, climatic conditions and energy performance are interrelated and have to be considered simultaneously as part of an optimised building design. In this paper, a new approach to evaluate the energy consumption of residential buildings in Morocco is presented. This approach is based on the effect of coupled heat and moisture transfer in typical residential buildings and on their responses to the varied climatic conditions encountered in the country. This approach allows us to evaluate with better accuracy the response of building energy performance and the indoor comfort of building occupants. Annual energy consumption, cooling and heating energy requirements were estimated considering the six climatic zones of Morocco. Based on the results, terms related to coupled heat and moisture transfer can effectively correct the existing energy consumption calculations of the six zones of Morocco, which currently do not consider energy consumption due to coupled heat and moisture transfer.